INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGING
Insulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with age. In the past two decades extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive function in multiple species including humans. Defici...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00027/full |
| _version_ | 1818254817037910016 |
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| author | William E Sonntag Ferenc eDeak Nicole eAshpole Anna eCsiszar Peter eToth Willard eFreeman Zoltan eUngvari |
| author_facet | William E Sonntag Ferenc eDeak Nicole eAshpole Anna eCsiszar Peter eToth Willard eFreeman Zoltan eUngvari |
| author_sort | William E Sonntag |
| collection | DOAJ |
| description | Insulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with age. In the past two decades extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive function in multiple species including humans. Deficiency in circulating IGF-1 results in impairment in processing speed and deficiencies in both spatial and working memory. Replacement of IGF-1 or factors that increase IGF-1 to old animals and humans reverses many of these cognitive deficits. Despite the overwhelming evidence for IGF-1 as an important neurotrophic agent, the specific mechanisms through which IGF-1 acts have remained elusive. Recent evidence indicates that IGF-1 is both produced by and has important actions on the cerebrovasculature as well as neurons and glia. Nevertheless, the specific regulation and actions of brain- and vascular-derived IGF-1 is poorly understood. The diverse effects of IGF-1 discovered thus far reveal a complex endocrine and paracrine system essential for integrating many of the functions necessary for brain health. Identification of the mechanisms of IGF-1 actions will undoubtedly provide critical insight into regulation of brain function in general and the causes of cognitive decline with age. |
| first_indexed | 2024-12-12T17:01:59Z |
| format | Article |
| id | doaj.art-9d5f837153ee4920bd8bc98d4f3843e7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T17:01:59Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-9d5f837153ee4920bd8bc98d4f3843e72022-12-22T00:18:06ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652013-07-01510.3389/fnagi.2013.0002754519INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGINGWilliam E Sonntag0Ferenc eDeak1Nicole eAshpole2Anna eCsiszar3Peter eToth4Willard eFreeman5Zoltan eUngvari6University of OklahomaUniversity of OklahomaUniversity of OklahomaUniversity of OklahomaUniversity of OklahomaPenn State College of MedicineUniversity of OklahomaInsulin-like growth factor-1 (IGF-1) is an important anabolic hormone that decreases with age. In the past two decades extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive function in multiple species including humans. Deficiency in circulating IGF-1 results in impairment in processing speed and deficiencies in both spatial and working memory. Replacement of IGF-1 or factors that increase IGF-1 to old animals and humans reverses many of these cognitive deficits. Despite the overwhelming evidence for IGF-1 as an important neurotrophic agent, the specific mechanisms through which IGF-1 acts have remained elusive. Recent evidence indicates that IGF-1 is both produced by and has important actions on the cerebrovasculature as well as neurons and glia. Nevertheless, the specific regulation and actions of brain- and vascular-derived IGF-1 is poorly understood. The diverse effects of IGF-1 discovered thus far reveal a complex endocrine and paracrine system essential for integrating many of the functions necessary for brain health. Identification of the mechanisms of IGF-1 actions will undoubtedly provide critical insight into regulation of brain function in general and the causes of cognitive decline with age.http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00027/fullAgingSynapsescognitive declineIGF-1vasculature |
| spellingShingle | William E Sonntag Ferenc eDeak Nicole eAshpole Anna eCsiszar Peter eToth Willard eFreeman Zoltan eUngvari INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGING Frontiers in Aging Neuroscience Aging Synapses cognitive decline IGF-1 vasculature |
| title | INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGING |
| title_full | INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGING |
| title_fullStr | INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGING |
| title_full_unstemmed | INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGING |
| title_short | INSULIN-LIKE GROWTH FACTOR (IGF)-1 IN CNS AND CEREBROVASCULAR AGING |
| title_sort | insulin like growth factor igf 1 in cns and cerebrovascular aging |
| topic | Aging Synapses cognitive decline IGF-1 vasculature |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00027/full |
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