Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

This study provides evidence that human topoisomerase IIIα (TOP3A) is closely associated with active replisomes. The authors uncover TOP3A DNA cleavage complexes (TOP3Accs) repair mechanisms to ensure normal DNA replication and genome integrity.

Bibliographic Details
Main Authors: Liton Kumar Saha, Sourav Saha, Xi Yang, Shar-yin Naomi Huang, Yilun Sun, Ukhyun Jo, Yves Pommier
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37498-6

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