IL-6 is associated to IGF-1Ec upregulation and Ec peptide secretion, from prostate tumors

IL-6 is associated to IGF-1Ec upregulation and Ec peptide secretion, from prostate tumors

Abstract Background Ec peptide (PEc), resulting from the proteolytic cleavage of the IGF-1Ec isoform, is involved in prostate cancer progression and metastasis, whereas in muscle tissue, it is associated with the mobilization of satellite cells prior to repair. Our aim is to determine the physiologi...

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Bibliographic Details
Main Authors: A. Armakolas, A. Dimakakos, C. Loukogiannaki, N. Armakolas, A. Antonopoulos, C. Florou, P. Tsioli, E. Papageorgiou, T. P. Alexandrou, M. Stathaki, D. Spinos, D. Pektasides, E. Patsouris, M. Koutsilieris
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Medicine
Subjects:
Immune response
IGF-1Ec
Il-6
Il-6R
JAK2/STAT3 pathway
MSCs mobilisation
Online Access:http://link.springer.com/article/10.1186/s10020-018-0003-z

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