Molecular Aspects of the Development and Function of Auditory Neurons
This review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric signals from sensory hair cells to the first auditory nuclei of the brain stem, the cochlear nuclei....
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/1/131 |
| _version_ | 1797543582902517760 |
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| author | Gabriela Pavlinkova |
| author_facet | Gabriela Pavlinkova |
| author_sort | Gabriela Pavlinkova |
| collection | DOAJ |
| description | This review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric signals from sensory hair cells to the first auditory nuclei of the brain stem, the cochlear nuclei. Congenital and acquired neurosensory hearing loss affects millions of people worldwide. An increasing body of evidence suggest that the primary auditory neurons degenerate due to noise exposure and aging more readily than sensory cells, and thus, auditory neurons are a primary target for regenerative therapy. A better understanding of the development and function of these neurons is the ultimate goal for long-term maintenance, regeneration, and stem cell replacement therapy. In this review, we provide an overview of the key molecular factors responsible for the function and neurogenesis of the primary auditory neurons, as well as a brief introduction to stem cell research focused on the replacement and generation of auditory neurons. |
| first_indexed | 2024-03-10T13:47:42Z |
| format | Article |
| id | doaj.art-9d68a57d24ad49fea180a39ea1db3165 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:47:42Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9d68a57d24ad49fea180a39ea1db31652023-11-21T02:30:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122113110.3390/ijms22010131Molecular Aspects of the Development and Function of Auditory NeuronsGabriela Pavlinkova0BIOCEV, Institute of Biotechnology of the Czech Academy of Sciences, 25250 Vestec, Czech RepublicThis review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric signals from sensory hair cells to the first auditory nuclei of the brain stem, the cochlear nuclei. Congenital and acquired neurosensory hearing loss affects millions of people worldwide. An increasing body of evidence suggest that the primary auditory neurons degenerate due to noise exposure and aging more readily than sensory cells, and thus, auditory neurons are a primary target for regenerative therapy. A better understanding of the development and function of these neurons is the ultimate goal for long-term maintenance, regeneration, and stem cell replacement therapy. In this review, we provide an overview of the key molecular factors responsible for the function and neurogenesis of the primary auditory neurons, as well as a brief introduction to stem cell research focused on the replacement and generation of auditory neurons.https://www.mdpi.com/1422-0067/22/1/131cochleasingle-cell RNAseqtranscription factorauditory pathwaysgenetic mutations |
| spellingShingle | Gabriela Pavlinkova Molecular Aspects of the Development and Function of Auditory Neurons International Journal of Molecular Sciences cochlea single-cell RNAseq transcription factor auditory pathways genetic mutations |
| title | Molecular Aspects of the Development and Function of Auditory Neurons |
| title_full | Molecular Aspects of the Development and Function of Auditory Neurons |
| title_fullStr | Molecular Aspects of the Development and Function of Auditory Neurons |
| title_full_unstemmed | Molecular Aspects of the Development and Function of Auditory Neurons |
| title_short | Molecular Aspects of the Development and Function of Auditory Neurons |
| title_sort | molecular aspects of the development and function of auditory neurons |
| topic | cochlea single-cell RNAseq transcription factor auditory pathways genetic mutations |
| url | https://www.mdpi.com/1422-0067/22/1/131 |
| work_keys_str_mv | AT gabrielapavlinkova molecularaspectsofthedevelopmentandfunctionofauditoryneurons |