Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research
There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current proces...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1000454/full |
| _version_ | 1811271859551862784 |
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| author | Christopher R. Andersen Christopher R. Andersen Christopher R. Andersen Shane W. English Shane W. English Anthony Delaney Anthony Delaney Anthony Delaney |
| author_facet | Christopher R. Andersen Christopher R. Andersen Christopher R. Andersen Shane W. English Shane W. English Anthony Delaney Anthony Delaney Anthony Delaney |
| author_sort | Christopher R. Andersen |
| collection | DOAJ |
| description | There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining “what” to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda. |
| first_indexed | 2024-04-12T22:28:35Z |
| format | Article |
| id | doaj.art-9d6a49a948da401eb8fae28b6f8face3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T22:28:35Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-9d6a49a948da401eb8fae28b6f8face32022-12-22T03:14:02ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.10004541000454Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage researchChristopher R. Andersen0Christopher R. Andersen1Christopher R. Andersen2Shane W. English3Shane W. English4Anthony Delaney5Anthony Delaney6Anthony Delaney7Northern Clinical School, Sydney University, Sydney, NSW, AustraliaThe George Institute for Global Health, UNSW, Sydney, NSW, AustraliaIntensive Care Department, Royal North Shore Hospital, Sydney, NSW, AustraliaDepartment of Medicine (Critical Care), uOttawa, Ottawa, ON, CanadaOttawa Hospital Research Institute (OHRI), Ottawa, ON, CanadaNorthern Clinical School, Sydney University, Sydney, NSW, AustraliaThe George Institute for Global Health, UNSW, Sydney, NSW, AustraliaIntensive Care Department, Royal North Shore Hospital, Sydney, NSW, AustraliaThere has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining “what” to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda.https://www.frontiersin.org/articles/10.3389/fneur.2022.1000454/fullsubarachnoid hemorrhageoutcome assessment (health care)core outcome set (COS)measurement instrumentspatient reported outcome measuresstroke |
| spellingShingle | Christopher R. Andersen Christopher R. Andersen Christopher R. Andersen Shane W. English Shane W. English Anthony Delaney Anthony Delaney Anthony Delaney Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research Frontiers in Neurology subarachnoid hemorrhage outcome assessment (health care) core outcome set (COS) measurement instruments patient reported outcome measures stroke |
| title | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
| title_full | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
| title_fullStr | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
| title_full_unstemmed | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
| title_short | Made to measure—Selecting outcomes in aneurysmal subarachnoid hemorrhage research |
| title_sort | made to measure selecting outcomes in aneurysmal subarachnoid hemorrhage research |
| topic | subarachnoid hemorrhage outcome assessment (health care) core outcome set (COS) measurement instruments patient reported outcome measures stroke |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1000454/full |
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