Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis
ABSTRACTObjective It is very important to develop a new therapeutic strategy to cope with the increasing morbidity and mortality of chronic kidney disease (CKD). As a kind of physical therapy, low intensity pulsed ultrasound (LIPUS) has remarkable anti-inflammatory and repair-promoting effects and i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Redox Report |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13510002.2023.2251237 |
| _version_ | 1797398784170262528 |
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| author | Zhi-Qiang Ouyang Li-shi Shao Wei-peng Wang Teng-fei Ke Dong Chen Guang-rong Zheng Xi-rui Duan Ji-xiang Chu Yu Zhu Lu Yang Hai-yan Shan Lin Huang Cheng-de Liao |
| author_facet | Zhi-Qiang Ouyang Li-shi Shao Wei-peng Wang Teng-fei Ke Dong Chen Guang-rong Zheng Xi-rui Duan Ji-xiang Chu Yu Zhu Lu Yang Hai-yan Shan Lin Huang Cheng-de Liao |
| author_sort | Zhi-Qiang Ouyang |
| collection | DOAJ |
| description | ABSTRACTObjective It is very important to develop a new therapeutic strategy to cope with the increasing morbidity and mortality of chronic kidney disease (CKD). As a kind of physical therapy, low intensity pulsed ultrasound (LIPUS) has remarkable anti-inflammatory and repair-promoting effects and is expected to become a new therapeutic method for CKD. This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.Methods A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.Results LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to oxidative stress and ferroptosis. In addition, the therapeutic effect of LIPUS is closely related to the regulation of TGF-β1/Smad and Nrf2/keap1/HO-1 signalling pathways.Discussion This study provides a new direction for further mechanism research and lays an important foundation for clinical trials. |
| first_indexed | 2024-03-09T01:30:30Z |
| format | Article |
| id | doaj.art-9d6cd50221604fe5851671b14756c997 |
| institution | Directory Open Access Journal |
| issn | 1351-0002 1743-2928 |
| language | English |
| last_indexed | 2024-03-09T01:30:30Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj.art-9d6cd50221604fe5851671b14756c9972023-12-09T20:05:02ZengTaylor & Francis GroupRedox Report1351-00021743-29282023-12-0128110.1080/13510002.2023.2251237Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosisZhi-Qiang Ouyang0Li-shi Shao1Wei-peng Wang2Teng-fei Ke3Dong Chen4Guang-rong Zheng5Xi-rui Duan6Ji-xiang Chu7Yu Zhu8Lu Yang9Hai-yan Shan10Lin Huang11Cheng-de Liao12Department of Radiology, Yan` an Hospital of Kunming City (Yanan Hospital Affiliated to Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Radiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, People’s Republic of ChinaDepartment of Radiology, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Ultrasound, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Radiology, Yan` an Hospital of Kunming City (Yanan Hospital Affiliated to Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Radiology, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Radiology, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Radiology, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Radiology, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, People’s Republic of ChinaDepartment of Radiology, Yan` an Hospital of Kunming City (Yanan Hospital Affiliated to Kunming Medical University), Kunming, People’s Republic of ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, People’s Republic of ChinaDepartment of Radiology, Yan` an Hospital of Kunming City (Yanan Hospital Affiliated to Kunming Medical University), Kunming, People’s Republic of ChinaABSTRACTObjective It is very important to develop a new therapeutic strategy to cope with the increasing morbidity and mortality of chronic kidney disease (CKD). As a kind of physical therapy, low intensity pulsed ultrasound (LIPUS) has remarkable anti-inflammatory and repair-promoting effects and is expected to become a new therapeutic method for CKD. This study aims to clarify the treatment effect of LIPUS on CKD-related renal inflammation and fibrosis, and to further explore the potential signal network of LIPUS treatment for ameliorating chronic renal injury.Methods A rat model simulating the progress of CKD was established by twice tail-vein injection of Adriamycin (ADR). Under anesthesia, bilateral kidneys of CKD rats were continuously stimulated by LIPUS for four weeks. The parameters of LIPUS were 1.0 MHz, 60 mW/cm2, 50% duty cycle and 20 min/d.Results LIPUS treatment effectively inhibited ADR-induced renal inflammation and fibrosis, and improved CKD-related to oxidative stress and ferroptosis. In addition, the therapeutic effect of LIPUS is closely related to the regulation of TGF-β1/Smad and Nrf2/keap1/HO-1 signalling pathways.Discussion This study provides a new direction for further mechanism research and lays an important foundation for clinical trials.https://www.tandfonline.com/doi/10.1080/13510002.2023.2251237Chronic kidney diseaseLow intensity pulsed ultrasoundInflammationFibrosisOxidative stressFerroptosis |
| spellingShingle | Zhi-Qiang Ouyang Li-shi Shao Wei-peng Wang Teng-fei Ke Dong Chen Guang-rong Zheng Xi-rui Duan Ji-xiang Chu Yu Zhu Lu Yang Hai-yan Shan Lin Huang Cheng-de Liao Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis Redox Report Chronic kidney disease Low intensity pulsed ultrasound Inflammation Fibrosis Oxidative stress Ferroptosis |
| title | Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis |
| title_full | Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis |
| title_fullStr | Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis |
| title_full_unstemmed | Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis |
| title_short | Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis |
| title_sort | low intensity pulsed ultrasound ameliorates adriamycin induced chronic renal injury by inhibiting ferroptosis |
| topic | Chronic kidney disease Low intensity pulsed ultrasound Inflammation Fibrosis Oxidative stress Ferroptosis |
| url | https://www.tandfonline.com/doi/10.1080/13510002.2023.2251237 |
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