Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran
Abstract This study was designed and implemented to analyze and establish documents related to the above cases in the first to third COVID-19 epidemic waves for the use of researchers and doctors during and after the epidemic. The current case series study was conducted on 24,563 thousand hospitaliz...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32292-2 |
| _version_ | 1797841019855699968 |
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| author | Seyedeh Mahideh Namayandeh HamidReza Dehghan Mohammad Hassan Lotfi Mohammad Reza Khajehaminian Saeed Hosseini Vali Bahrevar AliAkbar Jarrahi Fatemeh Majidpour |
| author_facet | Seyedeh Mahideh Namayandeh HamidReza Dehghan Mohammad Hassan Lotfi Mohammad Reza Khajehaminian Saeed Hosseini Vali Bahrevar AliAkbar Jarrahi Fatemeh Majidpour |
| author_sort | Seyedeh Mahideh Namayandeh |
| collection | DOAJ |
| description | Abstract This study was designed and implemented to analyze and establish documents related to the above cases in the first to third COVID-19 epidemic waves for the use of researchers and doctors during and after the epidemic. The current case series study was conducted on 24,563 thousand hospitalized COVID-19 patients by examining their clinical characteristics within a one-year period from the beginning of the pandemic on 02.22.2020 to 02.14.2021, which included the first to the third waves, based on gender and severity of COVID-19. The mean age of the participants was 56 ± 20.71, and 51.8% were male. Out of a total of 24,563 thousand hospitalized COVID-19 patients until February 2021, there were 2185 mortalities (9.8%) and 2559 cases of severe COVID-19 (13.1%). The median length of hospitalization from the time of admission to discharge or death in the hospital (IQR: 13–41) was estimated to be 21 days. The rate of hospital mortality was higher in severe (37.8%) than in non-severe (4.8%) cases of COVID-19, While the risk of severe cases increased significantly in the third (HR = 1.65, 95% CI: 1.46–1.87, P < 0.001) and early fourth waves (HR = 2.145, 95% CI: 1.7–2.71, P < 0.001). Also, the risk of contracting severe COVID-19 increased significantly in patients aged ≥ 65 years old (HR = 2.1, 95% CI 1.1.93–2.72, P < 0.001). As shown by the results, the rates of hospital mortality (9.3% vs. 8.5%) and severe cases of COVID-19 (13.6% vs. 12.5%) were higher among men than women (P < 0.01). In our study, the mortality rate and severity of COVID-19 were within the scope of global studies. Men experienced higher severity and mortality than women. The was a significantly higher prevalence of old age and underlying diseases in individuals with severe COVID-19. Our data also showed that patients with a previous history of COVID-19 had a more severe experience of COVID-19, while most of these patients were also significantly older and had an underlying disease. |
| first_indexed | 2024-04-09T16:24:06Z |
| format | Article |
| id | doaj.art-9d6e554eeb004159aa01dca0c98268e5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T16:24:06Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9d6e554eeb004159aa01dca0c98268e52023-04-23T11:17:13ZengNature PortfolioScientific Reports2045-23222023-04-0113111210.1038/s41598-023-32292-2Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of IranSeyedeh Mahideh Namayandeh0HamidReza Dehghan1Mohammad Hassan Lotfi2Mohammad Reza Khajehaminian3Saeed Hosseini4Vali Bahrevar5AliAkbar Jarrahi6Fatemeh Majidpour7Clinical Research Development Center, Afshar Hospital, Shahid Sadoughi University of Medical SciencesResearch Center for Health Technology Assessment and Medical Informatics, School of Public Health, Shahid Sadoughi University of Medical SciencesCenter for Healthcare Data Modeling, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Health in Emergency and Disaster, School of Public Health, Shahid Sadoughi University of Medical SciencesCenter for Healthcare Data Modeling, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Health Education & Health Promotion, Shahid Sadoughi University of Medical SciencesDeputy for Treatment, Shahid Sadoughi University of Medical SciencesClinical Research Development Center, Afshar Hospital, Shahid Sadoughi University of Medical SciencesAbstract This study was designed and implemented to analyze and establish documents related to the above cases in the first to third COVID-19 epidemic waves for the use of researchers and doctors during and after the epidemic. The current case series study was conducted on 24,563 thousand hospitalized COVID-19 patients by examining their clinical characteristics within a one-year period from the beginning of the pandemic on 02.22.2020 to 02.14.2021, which included the first to the third waves, based on gender and severity of COVID-19. The mean age of the participants was 56 ± 20.71, and 51.8% were male. Out of a total of 24,563 thousand hospitalized COVID-19 patients until February 2021, there were 2185 mortalities (9.8%) and 2559 cases of severe COVID-19 (13.1%). The median length of hospitalization from the time of admission to discharge or death in the hospital (IQR: 13–41) was estimated to be 21 days. The rate of hospital mortality was higher in severe (37.8%) than in non-severe (4.8%) cases of COVID-19, While the risk of severe cases increased significantly in the third (HR = 1.65, 95% CI: 1.46–1.87, P < 0.001) and early fourth waves (HR = 2.145, 95% CI: 1.7–2.71, P < 0.001). Also, the risk of contracting severe COVID-19 increased significantly in patients aged ≥ 65 years old (HR = 2.1, 95% CI 1.1.93–2.72, P < 0.001). As shown by the results, the rates of hospital mortality (9.3% vs. 8.5%) and severe cases of COVID-19 (13.6% vs. 12.5%) were higher among men than women (P < 0.01). In our study, the mortality rate and severity of COVID-19 were within the scope of global studies. Men experienced higher severity and mortality than women. The was a significantly higher prevalence of old age and underlying diseases in individuals with severe COVID-19. Our data also showed that patients with a previous history of COVID-19 had a more severe experience of COVID-19, while most of these patients were also significantly older and had an underlying disease.https://doi.org/10.1038/s41598-023-32292-2 |
| spellingShingle | Seyedeh Mahideh Namayandeh HamidReza Dehghan Mohammad Hassan Lotfi Mohammad Reza Khajehaminian Saeed Hosseini Vali Bahrevar AliAkbar Jarrahi Fatemeh Majidpour Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran Scientific Reports |
| title | Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran |
| title_full | Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran |
| title_fullStr | Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran |
| title_full_unstemmed | Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran |
| title_short | Clinical courses of 24,563 hospitalized COVID-19 patients during the first 12 months of the pandemic in the Central City of Iran |
| title_sort | clinical courses of 24 563 hospitalized covid 19 patients during the first 12 months of the pandemic in the central city of iran |
| url | https://doi.org/10.1038/s41598-023-32292-2 |
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