Toxic Effects of Domoic Acid in the Seabream Sparus aurata
Neurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg−1 bw. Mortality (6...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-10-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/8/10/2721/ |
| _version_ | 1817992155944189952 |
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| author | Vítor Vasconcelos Isabel Nogueira Alexandre Lobo-da-Cunha Rosa Cervantes Socorro Rivera Joana Azevedo Rogério Monteiro António Afonso Ana Gago-Martinez |
| author_facet | Vítor Vasconcelos Isabel Nogueira Alexandre Lobo-da-Cunha Rosa Cervantes Socorro Rivera Joana Azevedo Rogério Monteiro António Afonso Ana Gago-Martinez |
| author_sort | Vítor Vasconcelos |
| collection | DOAJ |
| description | Neurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg−1 bw. Mortality (66.67 ± 16.67%) was only observed in dose of 9.0 mg kg−1 bw. Signs of neurological toxicity were detected for the doses of 0.9 and 9.0 mg DA kg−1 bw. Furthermore, the mean concentrations (±SD) of DA detected by HPLC-UV in extracts of brain after exposure to 9.0 mg DA kg−1 bw were 0.61 ± 0.01, 0.96 ± 0.00, and 0.36 ± 0.01 mg DA kg−1 tissue at 1, 2, and 4 hours. The lack of major permanent brain damage in S. aurata, and reversibility of neurotoxic signs, suggest that lower susceptibility to DA or neuronal recovery occurs in affected individuals. |
| first_indexed | 2024-04-14T01:22:43Z |
| format | Article |
| id | doaj.art-9d7180c3fdb74555b237a4deebd1d2d9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:22:43Z |
| publishDate | 2010-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9d7180c3fdb74555b237a4deebd1d2d92022-12-22T02:20:35ZengMDPI AGMarine Drugs1660-33972010-10-018102721273210.3390/md8102721Toxic Effects of Domoic Acid in the Seabream Sparus aurataVítor VasconcelosIsabel NogueiraAlexandre Lobo-da-CunhaRosa CervantesSocorro RiveraJoana AzevedoRogério MonteiroAntónio AfonsoAna Gago-MartinezNeurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg−1 bw. Mortality (66.67 ± 16.67%) was only observed in dose of 9.0 mg kg−1 bw. Signs of neurological toxicity were detected for the doses of 0.9 and 9.0 mg DA kg−1 bw. Furthermore, the mean concentrations (±SD) of DA detected by HPLC-UV in extracts of brain after exposure to 9.0 mg DA kg−1 bw were 0.61 ± 0.01, 0.96 ± 0.00, and 0.36 ± 0.01 mg DA kg−1 tissue at 1, 2, and 4 hours. The lack of major permanent brain damage in S. aurata, and reversibility of neurotoxic signs, suggest that lower susceptibility to DA or neuronal recovery occurs in affected individuals.http://www.mdpi.com/1660-3397/8/10/2721/domoic acidamnesic shellfish poisoningPseudo-nitzschiaalgal neurotoxinSparus aurata |
| spellingShingle | Vítor Vasconcelos Isabel Nogueira Alexandre Lobo-da-Cunha Rosa Cervantes Socorro Rivera Joana Azevedo Rogério Monteiro António Afonso Ana Gago-Martinez Toxic Effects of Domoic Acid in the Seabream Sparus aurata Marine Drugs domoic acid amnesic shellfish poisoning Pseudo-nitzschia algal neurotoxin Sparus aurata |
| title | Toxic Effects of Domoic Acid in the Seabream Sparus aurata |
| title_full | Toxic Effects of Domoic Acid in the Seabream Sparus aurata |
| title_fullStr | Toxic Effects of Domoic Acid in the Seabream Sparus aurata |
| title_full_unstemmed | Toxic Effects of Domoic Acid in the Seabream Sparus aurata |
| title_short | Toxic Effects of Domoic Acid in the Seabream Sparus aurata |
| title_sort | toxic effects of domoic acid in the seabream sparus aurata |
| topic | domoic acid amnesic shellfish poisoning Pseudo-nitzschia algal neurotoxin Sparus aurata |
| url | http://www.mdpi.com/1660-3397/8/10/2721/ |
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