| Summary: | OBJECTIVE. This paper reviews literature and provides results of original trial data on early diagnostics of lung cancer (LC) with primary and work-up diagnostic procedures. MATERIAL AND METHODS. The pospective diagnostic data of 537 patients divided into 2 groups was analyzed: 1) panel study in early diagnostics of LC using low-dose computed tomography (369 patients) and 2) transthoracic core biopsy (168 patients). RESULTS. The pathological lesions in lung parenchyma, suspicious for early peripheral lung cancer, were detected in 24 % of study participants. The effectiveness of transthoracic core biopsy as diagnostic work-up method was 87.5 % and it correlated with nodule size and location in lungs parenchyma. CONCLUSION. The modern lung cancer diagnostics allows detecting the disease on the early stage and collecting the morphologic materials sufficiently enough for personalization of management algorithms.
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