Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females
BackgroundAdipokines are engaged in bone physiology and regulate bone mineral density (BMD) by playing protective or cynical role in bone metabolism. The study is designed to measure and compare BMD, adipokines (retinoic acid receptor responder protein-2 RARRES2, visfatin and Intelectin-1) and their...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1024860/full |
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| author | Sundus Tariq Saba Tariq Saba Khaliq Shahad Abduljalil Abualhamael Mukhtiar Baig |
| author_facet | Sundus Tariq Saba Tariq Saba Khaliq Shahad Abduljalil Abualhamael Mukhtiar Baig |
| author_sort | Sundus Tariq |
| collection | DOAJ |
| description | BackgroundAdipokines are engaged in bone physiology and regulate bone mineral density (BMD) by playing protective or cynical role in bone metabolism. The study is designed to measure and compare BMD, adipokines (retinoic acid receptor responder protein-2 RARRES2, visfatin and Intelectin-1) and their genetic variants in postmenopausal osteoporotic, osteopenic and non-osteoporotic females.MethodsThis comparative study included postmenopausal non-osteoporotic (n=72), osteopenic (n=72) and osteoporotic (n=100) females with two years of amenorrhea and age between 50 to 70 years. Gold standard DXA was used to measure BMD. Hardy-Weinberg equilibrium was established. Kruskal-Wallis test for comparisons, logistic and multivariate regression analysis were used to rule out the predictors of BMD.ResultsOn comparing the three groups, significant differences were observed in serum RARRES2 (p <0.001) and serum visfatin (p=0.050). The significant positive predictor of BMD at lumbar spine and total hip was serum visfatin. BMD at right and left femoral neck was predicted negatively by serum chemerin while BMD at left femoral neck was also predicted positively by serum calcium levels. There was significant difference in BMD at right femoral neck (p = 0.033) between rs7806429 genotypes. The odds of having low BMD increases with increasing serum levels of chemerin and decreasing serum levels of visfatin and calciumConclusionThe adipokines RARRES2 and visfatin are associated with BMD. RARRES2 is an independent negative and visfatin is positive predictor of BMD in postmenopausal females. BMD at right femoral neck was significantly low in RARRES2 rs7806429 TC heterozygotes. |
| first_indexed | 2024-04-11T15:53:45Z |
| format | Article |
| id | doaj.art-9d723a8ecad542758851b3d0e0081ea7 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T15:53:45Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9d723a8ecad542758851b3d0e0081ea72022-12-22T04:15:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10248601024860Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal femalesSundus Tariq0Saba Tariq1Saba Khaliq2Shahad Abduljalil Abualhamael3Mukhtiar Baig4Department of Physiology, University Medical & Dental College, The University of Faisalabad, Faisalabad, PakistanDepartment of Pharmacology and Therapeutics, University Medical & Dental College, The University of Faisalabad, Faisalabad, PakistanDepartment of Physiology and Cell Biology, University of Health Sciences, Lahore, PakistanDepartment of Internal Medicine, Faculty of Medicine Rabigh, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Clinical Biochemistry, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi ArabiaBackgroundAdipokines are engaged in bone physiology and regulate bone mineral density (BMD) by playing protective or cynical role in bone metabolism. The study is designed to measure and compare BMD, adipokines (retinoic acid receptor responder protein-2 RARRES2, visfatin and Intelectin-1) and their genetic variants in postmenopausal osteoporotic, osteopenic and non-osteoporotic females.MethodsThis comparative study included postmenopausal non-osteoporotic (n=72), osteopenic (n=72) and osteoporotic (n=100) females with two years of amenorrhea and age between 50 to 70 years. Gold standard DXA was used to measure BMD. Hardy-Weinberg equilibrium was established. Kruskal-Wallis test for comparisons, logistic and multivariate regression analysis were used to rule out the predictors of BMD.ResultsOn comparing the three groups, significant differences were observed in serum RARRES2 (p <0.001) and serum visfatin (p=0.050). The significant positive predictor of BMD at lumbar spine and total hip was serum visfatin. BMD at right and left femoral neck was predicted negatively by serum chemerin while BMD at left femoral neck was also predicted positively by serum calcium levels. There was significant difference in BMD at right femoral neck (p = 0.033) between rs7806429 genotypes. The odds of having low BMD increases with increasing serum levels of chemerin and decreasing serum levels of visfatin and calciumConclusionThe adipokines RARRES2 and visfatin are associated with BMD. RARRES2 is an independent negative and visfatin is positive predictor of BMD in postmenopausal females. BMD at right femoral neck was significantly low in RARRES2 rs7806429 TC heterozygotes.https://www.frontiersin.org/articles/10.3389/fendo.2022.1024860/fullBMDosteoporosisintelectin-1RARRES2adipokinesvisfatin/NAMPT |
| spellingShingle | Sundus Tariq Saba Tariq Saba Khaliq Shahad Abduljalil Abualhamael Mukhtiar Baig Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females Frontiers in Endocrinology BMD osteoporosis intelectin-1 RARRES2 adipokines visfatin/NAMPT |
| title | Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females |
| title_full | Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females |
| title_fullStr | Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females |
| title_full_unstemmed | Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females |
| title_short | Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females |
| title_sort | association of serum levels of visfatin intelectin 1 rarres2 and their genetic variants with bone mineral density in postmenopausal females |
| topic | BMD osteoporosis intelectin-1 RARRES2 adipokines visfatin/NAMPT |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1024860/full |
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