Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature Review
Introduction Thrombocytosis is a common disorder in patients diagnosed with iron deficiency anemia. The decreased platelet counts commonly found iron deficiency anemia is rarely reported in clinical practice. The exact mechanism of the occurrence of thrombocytopenia in iron deficiency anemia remains...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-01-01
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| Series: | Clinical Medicine Insights: Case Reports |
| Online Access: | https://doi.org/10.4137/CCRep.S9329 |
| _version_ | 1819082779087863808 |
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| author | Ramy Ibrahim Areej Khan Shahzad Raza Muhammad Kafeel Ridhima Dabas Elizabeth Haynes Anjula Gandhi Omran L. Majumder Mohammad Zaman |
| author_facet | Ramy Ibrahim Areej Khan Shahzad Raza Muhammad Kafeel Ridhima Dabas Elizabeth Haynes Anjula Gandhi Omran L. Majumder Mohammad Zaman |
| author_sort | Ramy Ibrahim |
| collection | DOAJ |
| description | Introduction Thrombocytosis is a common disorder in patients diagnosed with iron deficiency anemia. The decreased platelet counts commonly found iron deficiency anemia is rarely reported in clinical practice. The exact mechanism of the occurrence of thrombocytopenia in iron deficiency anemia remains unclear. In this case report we discuss a triad of symptoms seen in the African American population: Iron deficiency anemia, menorrhagia and thrombocytopenia. Case presentation A 40 year old multiparous African-American woman presented with heavy vaginal bleed, severe anemia (3.5 g/dL) and thrombocytopenia (30,000/mm 3 ). The peripheral blood smear showed marked microcytic hypochromic cells with decreased platelets counts. After excluding other causes of thrombocytopenia and anemia, increased red cell distribution width and low iron saturation confirmed the diagnosis of iron deficiency anemia. Treatment for iron deficiency anemia was initiated with intravenous and oral iron supplements. Two months following treatment of iron deficiency anemia, the triad of manifestations resolved and patient remained stable. Conclusion Profound degree of iron deficiency anemia can present with thrombocytopenia and severe menorrhagia. Iron replacement should be the main treatment goal in these patients. This case report further supports the 2 compartment model of the role of iron in maintaining platelet counts. |
| first_indexed | 2024-12-21T20:22:05Z |
| format | Article |
| id | doaj.art-9d725c0a7e554635893097b62cd43232 |
| institution | Directory Open Access Journal |
| issn | 1179-5476 |
| language | English |
| last_indexed | 2024-12-21T20:22:05Z |
| publishDate | 2012-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Case Reports |
| spelling | doaj.art-9d725c0a7e554635893097b62cd432322022-12-21T18:51:28ZengSAGE PublishingClinical Medicine Insights: Case Reports1179-54762012-01-01510.4137/CCRep.S9329Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature ReviewRamy Ibrahim0Areej Khan1Shahzad Raza2Muhammad Kafeel3Ridhima Dabas4Elizabeth Haynes5Anjula Gandhi6Omran L. Majumder7Mohammad Zaman8Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.Introduction Thrombocytosis is a common disorder in patients diagnosed with iron deficiency anemia. The decreased platelet counts commonly found iron deficiency anemia is rarely reported in clinical practice. The exact mechanism of the occurrence of thrombocytopenia in iron deficiency anemia remains unclear. In this case report we discuss a triad of symptoms seen in the African American population: Iron deficiency anemia, menorrhagia and thrombocytopenia. Case presentation A 40 year old multiparous African-American woman presented with heavy vaginal bleed, severe anemia (3.5 g/dL) and thrombocytopenia (30,000/mm 3 ). The peripheral blood smear showed marked microcytic hypochromic cells with decreased platelets counts. After excluding other causes of thrombocytopenia and anemia, increased red cell distribution width and low iron saturation confirmed the diagnosis of iron deficiency anemia. Treatment for iron deficiency anemia was initiated with intravenous and oral iron supplements. Two months following treatment of iron deficiency anemia, the triad of manifestations resolved and patient remained stable. Conclusion Profound degree of iron deficiency anemia can present with thrombocytopenia and severe menorrhagia. Iron replacement should be the main treatment goal in these patients. This case report further supports the 2 compartment model of the role of iron in maintaining platelet counts.https://doi.org/10.4137/CCRep.S9329 |
| spellingShingle | Ramy Ibrahim Areej Khan Shahzad Raza Muhammad Kafeel Ridhima Dabas Elizabeth Haynes Anjula Gandhi Omran L. Majumder Mohammad Zaman Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature Review Clinical Medicine Insights: Case Reports |
| title | Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature Review |
| title_full | Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature Review |
| title_fullStr | Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature Review |
| title_full_unstemmed | Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature Review |
| title_short | Triad of Iron Deficiency Anemia, Severe Thrombocytopenia and Menorrhagia–-A Case Report and Literature Review |
| title_sort | triad of iron deficiency anemia severe thrombocytopenia and menorrhagia a case report and literature review |
| url | https://doi.org/10.4137/CCRep.S9329 |
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