Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease
Both abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson’s disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients wit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncir.2019.00025/full |
| _version_ | 1828223352857165824 |
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| author | Sheng Hu Hongli Wu ChunSheng Xu Anqin Wang Yi Wang Tongping Shen Fangliang Huang Hongxing Kan Chuanfu Li |
| author_facet | Sheng Hu Hongli Wu ChunSheng Xu Anqin Wang Yi Wang Tongping Shen Fangliang Huang Hongxing Kan Chuanfu Li |
| author_sort | Sheng Hu |
| collection | DOAJ |
| description | Both abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson’s disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients with WD and 27 sex- and age-matched healthy controls were recruited to acquire functional MRI and arterial spin labeling imaging data. Functional connectivity strength (FCS) and CBF were calculated based on standard gray mask. Compared to healthy controls, the CBF–FCS correlations of patients with WD were significantly decreased in the basal ganglia and the cerebellum and slightly increased in the prefrontal cortex and thalamus. In contrast, decreased CBF of patients with WD occurred predominately in subcortical and cognitive- and emotion-related brain regions, including the basal ganglia, thalamus, insular, and inferior prefrontal cortex, whereas increased CBF occurred primarily in the temporal cortex. The FCS decrease in WD patients was predominately in the basal ganglia and thalamus, and the increase was primarily in the prefrontal cortex. These findings suggest that aberrant neurovascular coupling in the brain may be a possible neuropathological mechanism underlying WD. |
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| id | doaj.art-9d72f16cae564dba9e3339c0fca009cc |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-12T17:06:19Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-9d72f16cae564dba9e3339c0fca009cc2022-12-22T03:23:56ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102019-04-011310.3389/fncir.2019.00025430566Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s DiseaseSheng Hu0Hongli Wu1ChunSheng Xu2Anqin Wang3Yi Wang4Tongping Shen5Fangliang Huang6Hongxing Kan7Chuanfu Li8Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaMedical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaLaboratory of Digital Medical Imaging, Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaLaboratory of Digital Medical Imaging, Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaMedical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaMedical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaMedical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaMedical Information Engineering, Anhui University of Chinese Medicine, Hefei, ChinaLaboratory of Digital Medical Imaging, Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaBoth abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson’s disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients with WD and 27 sex- and age-matched healthy controls were recruited to acquire functional MRI and arterial spin labeling imaging data. Functional connectivity strength (FCS) and CBF were calculated based on standard gray mask. Compared to healthy controls, the CBF–FCS correlations of patients with WD were significantly decreased in the basal ganglia and the cerebellum and slightly increased in the prefrontal cortex and thalamus. In contrast, decreased CBF of patients with WD occurred predominately in subcortical and cognitive- and emotion-related brain regions, including the basal ganglia, thalamus, insular, and inferior prefrontal cortex, whereas increased CBF occurred primarily in the temporal cortex. The FCS decrease in WD patients was predominately in the basal ganglia and thalamus, and the increase was primarily in the prefrontal cortex. These findings suggest that aberrant neurovascular coupling in the brain may be a possible neuropathological mechanism underlying WD.https://www.frontiersin.org/article/10.3389/fncir.2019.00025/fullneurovascular couplingbasal gangliaarterial spin labelingcerebral blood flowfunctional magnetic resonance imaging |
| spellingShingle | Sheng Hu Hongli Wu ChunSheng Xu Anqin Wang Yi Wang Tongping Shen Fangliang Huang Hongxing Kan Chuanfu Li Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease Frontiers in Neural Circuits neurovascular coupling basal ganglia arterial spin labeling cerebral blood flow functional magnetic resonance imaging |
| title | Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease |
| title_full | Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease |
| title_fullStr | Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease |
| title_full_unstemmed | Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease |
| title_short | Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease |
| title_sort | aberrant coupling between resting state cerebral blood flow and functional connectivity in wilson s disease |
| topic | neurovascular coupling basal ganglia arterial spin labeling cerebral blood flow functional magnetic resonance imaging |
| url | https://www.frontiersin.org/article/10.3389/fncir.2019.00025/full |
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