Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart Review
The aim of our study was to evaluate the effectiveness of lurasidone augmentation of clozapine in treatment-resistant schizophrenia (SZ) in a retrospective chart review. From the medical records of 916 SZ patients, we identified 16 individuals treated with a combination of clozapine and lurasidone....
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MDPI AG
2023-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/3/445 |
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| author | Marcin Siwek Adrian Andrzej Chrobak Aleksandra Gorostowicz Patrycja Król Dominika Dudek |
| author_facet | Marcin Siwek Adrian Andrzej Chrobak Aleksandra Gorostowicz Patrycja Król Dominika Dudek |
| author_sort | Marcin Siwek |
| collection | DOAJ |
| description | The aim of our study was to evaluate the effectiveness of lurasidone augmentation of clozapine in treatment-resistant schizophrenia (SZ) in a retrospective chart review. From the medical records of 916 SZ patients, we identified 16 individuals treated with a combination of clozapine and lurasidone. The detailed clinical data are described separately for each patient. We compared the Clinical Global Impression—Severity (CGI-S) scores between three points of observation: before the treatment and one month and two months after its initiation. CGI Improvement (CGI-I) scores were used to evaluate the treatment response between the first and last points of observation. The vast majority of patients (14/16, 87.5%) responded to lurasidone augmentation of clozapine (CGI-I scores 1 or 2). Therapeutic effects were observable after 3–12 weeks of treatment (median 6 (4–6)). A reduction in CGI-S scores was observed after the first month of observation. There was an observable reduction in positive, depressive and anxiety symptoms, as well as an improvement in psychosocial functioning. Two patients discontinued treatment due to side effects. Our study suggests that lurasidone augmentation of clozapine may lead to improvements in a broad range of SZ symptom dimensions. |
| first_indexed | 2024-03-11T06:50:48Z |
| format | Article |
| id | doaj.art-9d737a2e30e843939a2a279c9e63069f |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T06:50:48Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-9d737a2e30e843939a2a279c9e63069f2023-11-17T09:59:55ZengMDPI AGBrain Sciences2076-34252023-03-0113344510.3390/brainsci13030445Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart ReviewMarcin Siwek0Adrian Andrzej Chrobak1Aleksandra Gorostowicz2Patrycja Król3Dominika Dudek4Department of Affective Disorders, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandDepartment of Adult Psychiatry, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandDepartment of Adult Psychiatry, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandDepartment of Adult, Child and Adolescent Psychiatry, University Hospital in Cracow, Kopernika St. 21a, 31-501 Cracow, PolandDepartment of Adult Psychiatry, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Cracow, PolandThe aim of our study was to evaluate the effectiveness of lurasidone augmentation of clozapine in treatment-resistant schizophrenia (SZ) in a retrospective chart review. From the medical records of 916 SZ patients, we identified 16 individuals treated with a combination of clozapine and lurasidone. The detailed clinical data are described separately for each patient. We compared the Clinical Global Impression—Severity (CGI-S) scores between three points of observation: before the treatment and one month and two months after its initiation. CGI Improvement (CGI-I) scores were used to evaluate the treatment response between the first and last points of observation. The vast majority of patients (14/16, 87.5%) responded to lurasidone augmentation of clozapine (CGI-I scores 1 or 2). Therapeutic effects were observable after 3–12 weeks of treatment (median 6 (4–6)). A reduction in CGI-S scores was observed after the first month of observation. There was an observable reduction in positive, depressive and anxiety symptoms, as well as an improvement in psychosocial functioning. Two patients discontinued treatment due to side effects. Our study suggests that lurasidone augmentation of clozapine may lead to improvements in a broad range of SZ symptom dimensions.https://www.mdpi.com/2076-3425/13/3/445clozapine resistancetreatment resistanceaugmentationschizophrenia |
| spellingShingle | Marcin Siwek Adrian Andrzej Chrobak Aleksandra Gorostowicz Patrycja Król Dominika Dudek Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart Review Brain Sciences clozapine resistance treatment resistance augmentation schizophrenia |
| title | Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart Review |
| title_full | Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart Review |
| title_fullStr | Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart Review |
| title_full_unstemmed | Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart Review |
| title_short | Lurasidone Augmentation of Clozapine in Schizophrenia—Retrospective Chart Review |
| title_sort | lurasidone augmentation of clozapine in schizophrenia retrospective chart review |
| topic | clozapine resistance treatment resistance augmentation schizophrenia |
| url | https://www.mdpi.com/2076-3425/13/3/445 |
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