Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage

Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage

Introduction: Irisin plays an important role in regulating tissue stress, cardiac function, and inflammation. Integrin αvβ5 was recently identified as a receptor for irisin to elicit its physiologic function. It remains unknown whether integrin αvβ5 is required for irisin's function in modulati...

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Bibliographic Details
Main Authors: Lijiang Wang, Supaporn Kulthinee, John Slate-Romano, Thomas Zhao, Hamsa Shanmugam, Patrycja M Dubielecka, Ling X. Zhang, Gangjian Qin, Shougang Zhuang, Y. Eugene Chin, Ting C. Zhao
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Experimental and Molecular Pathology
Subjects:
Hemorrhage
Irisin, integrin αvβ5
Cardiac function
Organ failure
Stresses
Online Access:http://www.sciencedirect.com/science/article/pii/S0014480023000205

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