Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain
Zhiyun Zhang, Hao Zheng, Qingquan Yu, Xianghong Jing Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Xianghong Jing, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, P...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/understanding-of-spinal-wide-dynamic-range-neurons-and-their-modulatio-peer-reviewed-fulltext-article-JPR |
| _version_ | 1797335724537675776 |
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| author | Zhang Z Zheng H Yu Q Jing X |
| author_facet | Zhang Z Zheng H Yu Q Jing X |
| author_sort | Zhang Z |
| collection | DOAJ |
| description | Zhiyun Zhang, Hao Zheng, Qingquan Yu, Xianghong Jing Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Xianghong Jing, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China, Email jxhtjb@263.netAbstract: The spinal dorsal horn (SDH) transmits sensory information from the periphery to the brain. Wide dynamic range (WDR) neurons within this relay site play a critical role in modulating and integrating peripheral sensory inputs, as well as the process of central sensitization during pathological pain. This group of spinal multi-receptive neurons has attracted considerable attention in pain research due to their capabilities for encoding the location and intensity of nociception. Meanwhile, transmission, processing, and modulation of incoming afferent information in WDR neurons also establish the underlying basis for investigating the integration of acupuncture and pain signals. This review aims to provide a comprehensive examination of the distinctive features of WDR neurons and their involvement in pain. Specifically, we will examine the regulation of diverse supraspinal nuclei on these neurons and analyze their potential in elucidating the mechanisms of acupuncture analgesia.Keywords: WDR neurons, spinal dorsal horn, pain, central sensitization, receptive fields, DNIC, acupuncture analgesia |
| first_indexed | 2024-03-08T08:42:32Z |
| format | Article |
| id | doaj.art-9d776b626adf4d3a83e6db862147370b |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-03-08T08:42:32Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-9d776b626adf4d3a83e6db862147370b2024-02-01T17:59:27ZengDove Medical PressJournal of Pain Research1178-70902024-02-01Volume 1744145790136Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological PainZhang ZZheng HYu QJing XZhiyun Zhang, Hao Zheng, Qingquan Yu, Xianghong Jing Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of ChinaCorrespondence: Xianghong Jing, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China, Email jxhtjb@263.netAbstract: The spinal dorsal horn (SDH) transmits sensory information from the periphery to the brain. Wide dynamic range (WDR) neurons within this relay site play a critical role in modulating and integrating peripheral sensory inputs, as well as the process of central sensitization during pathological pain. This group of spinal multi-receptive neurons has attracted considerable attention in pain research due to their capabilities for encoding the location and intensity of nociception. Meanwhile, transmission, processing, and modulation of incoming afferent information in WDR neurons also establish the underlying basis for investigating the integration of acupuncture and pain signals. This review aims to provide a comprehensive examination of the distinctive features of WDR neurons and their involvement in pain. Specifically, we will examine the regulation of diverse supraspinal nuclei on these neurons and analyze their potential in elucidating the mechanisms of acupuncture analgesia.Keywords: WDR neurons, spinal dorsal horn, pain, central sensitization, receptive fields, DNIC, acupuncture analgesiahttps://www.dovepress.com/understanding-of-spinal-wide-dynamic-range-neurons-and-their-modulatio-peer-reviewed-fulltext-article-JPRwdr neuronsspinal dorsal hornpaincentral sensitizationreceptive fieldsdnicacupuncture analgesia |
| spellingShingle | Zhang Z Zheng H Yu Q Jing X Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain Journal of Pain Research wdr neurons spinal dorsal horn pain central sensitization receptive fields dnic acupuncture analgesia |
| title | Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain |
| title_full | Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain |
| title_fullStr | Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain |
| title_full_unstemmed | Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain |
| title_short | Understanding of Spinal Wide Dynamic Range Neurons and Their Modulation on Pathological Pain |
| title_sort | understanding of spinal wide dynamic range neurons and their modulation on pathological pain |
| topic | wdr neurons spinal dorsal horn pain central sensitization receptive fields dnic acupuncture analgesia |
| url | https://www.dovepress.com/understanding-of-spinal-wide-dynamic-range-neurons-and-their-modulatio-peer-reviewed-fulltext-article-JPR |
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