Detection of ERBB2 (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort

Detection of ERBB2 (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort

Background: HER2 antagonists have marked activity and are approved for the treatment of HER2 overexpressing breast and gastric cancers. Recent studies have shown that ERBB2 (HER2) gene amplification and overexpression may also be actionable in other tumor types. Inter- and intratumoral heterogeneity...

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Bibliographic Details
Main Authors: Jeeyun Lee, Aleksandra Franovic, Yukimasa Shiotsu, Seung Tae Kim, Kyoung-Mee Kim, Kimberly C. Banks, Victoria M. Raymond, Richard B. Lanman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
cfDNA
ERBB2
HER2
liquid biopsy
NGS
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00212/full

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