Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review
Aim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI). Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation, paediatric, dexmedetomidine, ambulatory, MRI, keta...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2023-02-01
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| Series: | Medicinski Glasnik |
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| Online Access: | https://ljkzedo.ba/mgpdf/mg38/05_Vitraludyono_1532_A.pdf |
| _version_ | 1827862434076950528 |
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| author | Rudy Vitraludyono Arie Utariani Elizeus Hanindito |
| author_facet | Rudy Vitraludyono Arie Utariani Elizeus Hanindito |
| author_sort | Rudy Vitraludyono |
| collection | DOAJ |
| description | Aim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI).
Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation, paediatric, dexmedetomidine, ambulatory, MRI, ketamine, propofol, midazolam. The literature selection was based on Participant, Intervention, Comparators, Outcomes (PICO) analysis. All English full-text and peer-reviewed articles were included. The primary outcome was hemodynamic stability, respiratory compromise, and recovery time. The risk of bias analysis was assessed using Cochrane collaboration Risk of Bias (RoB 2.0).
Result Of 106 studies, 17 studies were included with a total 3.430 paediatric patients undergoing MRI. Dexmedetomidine alone provides a more stable hemodynamic but longer recovery time than ketamine, propofol or midazolam. The combination of dexmedetomidine and ketamine provides more stable hemodynamics, especially in the incidence of hypotension and bradycardia, and does not significantly reduce airway configuration more than sole dexmedetomidine or ketamine. Intranasal dexmedetomidine is more recommended than its combination with midazolam. Combining dexmedetomidine with ketamine, propofol or midazolam provides a shorter recovery time.
Conclusion A combination of dexmedetomidine with other sedatives such as ketamine, propofol and midazolam is better than sole dexmedetomidine for paediatric sedation during magnetic resonance imaging. |
| first_indexed | 2024-03-12T13:55:10Z |
| format | Article |
| id | doaj.art-9d79430c22384d2ba45ddbf66f0e7d45 |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-03-12T13:55:10Z |
| publishDate | 2023-02-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-9d79430c22384d2ba45ddbf66f0e7d452023-08-22T17:01:38ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452023-02-0120171410.17392/1532-22Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic reviewRudy Vitraludyono0Arie Utariani1Elizeus Hanindito2Department of Anaesthesiology and ReanimationConsultant of Paediatric Anaesthesia, Department of Anaesthesiology and Reanimation; Faculty of Medicine, Airlangga University/ Dr. Soetomo General Hospital, Surabaya, IndonesiaConsultant of Paediatric Anaesthesia, Department of Anaesthesiology and Reanimation; Faculty of Medicine, Airlangga University/ Dr. Soetomo General Hospital, Surabaya, IndonesiaAim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI). Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation, paediatric, dexmedetomidine, ambulatory, MRI, ketamine, propofol, midazolam. The literature selection was based on Participant, Intervention, Comparators, Outcomes (PICO) analysis. All English full-text and peer-reviewed articles were included. The primary outcome was hemodynamic stability, respiratory compromise, and recovery time. The risk of bias analysis was assessed using Cochrane collaboration Risk of Bias (RoB 2.0). Result Of 106 studies, 17 studies were included with a total 3.430 paediatric patients undergoing MRI. Dexmedetomidine alone provides a more stable hemodynamic but longer recovery time than ketamine, propofol or midazolam. The combination of dexmedetomidine and ketamine provides more stable hemodynamics, especially in the incidence of hypotension and bradycardia, and does not significantly reduce airway configuration more than sole dexmedetomidine or ketamine. Intranasal dexmedetomidine is more recommended than its combination with midazolam. Combining dexmedetomidine with ketamine, propofol or midazolam provides a shorter recovery time. Conclusion A combination of dexmedetomidine with other sedatives such as ketamine, propofol and midazolam is better than sole dexmedetomidine for paediatric sedation during magnetic resonance imaging.https://ljkzedo.ba/mgpdf/mg38/05_Vitraludyono_1532_A.pdfanaesthesiaketaminemidazolampropofol |
| spellingShingle | Rudy Vitraludyono Arie Utariani Elizeus Hanindito Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review Medicinski Glasnik anaesthesia ketamine midazolam propofol |
| title | Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review |
| title_full | Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review |
| title_fullStr | Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review |
| title_full_unstemmed | Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review |
| title_short | Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review |
| title_sort | comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging a systematic review |
| topic | anaesthesia ketamine midazolam propofol |
| url | https://ljkzedo.ba/mgpdf/mg38/05_Vitraludyono_1532_A.pdf |
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