Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold Loading
This study aims to investigate noninvasive indices of neuromechanical coupling (NMC) and mechanical efficiency (MEff) of parasternal intercostal muscles. Gold standard assessment of diaphragm NMC requires using invasive techniques, limiting the utility of this procedure. Noninvasive NMC indices of p...
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MDPI AG
2021-03-01
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| Online Access: | https://www.mdpi.com/1424-8220/21/5/1781 |
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| author | Manuel Lozano-García Luis Estrada-Petrocelli Abel Torres Gerrard F. Rafferty John Moxham Caroline J. Jolley Raimon Jané |
| author_facet | Manuel Lozano-García Luis Estrada-Petrocelli Abel Torres Gerrard F. Rafferty John Moxham Caroline J. Jolley Raimon Jané |
| author_sort | Manuel Lozano-García |
| collection | DOAJ |
| description | This study aims to investigate noninvasive indices of neuromechanical coupling (NMC) and mechanical efficiency (MEff) of parasternal intercostal muscles. Gold standard assessment of diaphragm NMC requires using invasive techniques, limiting the utility of this procedure. Noninvasive NMC indices of parasternal intercostal muscles can be calculated using surface mechanomyography (sMMG<sub>para</sub>) and electromyography (sEMG<sub>para</sub>). However, the use of sMMG<sub>para</sub> as an inspiratory muscle mechanical output measure, and the relationships between sMMG<sub>para</sub>, sEMG<sub>para</sub>, and simultaneous invasive and noninvasive pressure measurements have not previously been evaluated. sEMG<sub>para</sub>, sMMG<sub>para</sub>, and both invasive and noninvasive measurements of pressures were recorded in twelve healthy subjects during an inspiratory loading protocol. The ratios of sMMG<sub>para</sub> to sEMG<sub>para</sub>, which provided muscle-specific noninvasive NMC indices of parasternal intercostal muscles, showed nonsignificant changes with increasing load, since the relationships between sMMG<sub>para</sub> and sEMG<sub>para</sub> were linear (R<sup>2</sup> = 0.85 (0.75–0.9)). The ratios of mouth pressure (P<sub>mo</sub>) to sEMG<sub>para</sub> and sMMG<sub>para</sub> were also proposed as noninvasive indices of parasternal intercostal muscle NMC and MEff, respectively. These indices, similar to the analogous indices calculated using invasive transdiaphragmatic and esophageal pressures, showed nonsignificant changes during threshold loading, since the relationships between P<sub>mo</sub> and both sEMG<sub>para</sub> (R<sup>2</sup> = 0.84 (0.77–0.93)) and sMMG<sub>para</sub> (R<sup>2</sup> = 0.89 (0.85–0.91)) were linear. The proposed noninvasive NMC and MEff indices of parasternal intercostal muscles may be of potential clinical value, particularly for the regular assessment of patients with disordered respiratory mechanics using noninvasive wearable and wireless devices. |
| first_indexed | 2024-03-09T05:33:31Z |
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| publishDate | 2021-03-01 |
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| spelling | doaj.art-9d7a85bc84b0447c9d9a924714c8828f2023-12-03T12:31:00ZengMDPI AGSensors1424-82202021-03-01215178110.3390/s21051781Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold LoadingManuel Lozano-García0Luis Estrada-Petrocelli1Abel Torres2Gerrard F. Rafferty3John Moxham4Caroline J. Jolley5Raimon Jané6Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), UPC Campus Diagonal-Besòs, Av. d’Eduard Maristany 10–14, 08019 Barcelona, SpainInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), UPC Campus Diagonal-Besòs, Av. d’Eduard Maristany 10–14, 08019 Barcelona, SpainInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), UPC Campus Diagonal-Besòs, Av. d’Eduard Maristany 10–14, 08019 Barcelona, SpainCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King’s College London, King’s Health Partners, London SE1 9RT, UKCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King’s College London, King’s Health Partners, London SE1 9RT, UKCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King’s College London, King’s Health Partners, London SE1 9RT, UKInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), UPC Campus Diagonal-Besòs, Av. d’Eduard Maristany 10–14, 08019 Barcelona, SpainThis study aims to investigate noninvasive indices of neuromechanical coupling (NMC) and mechanical efficiency (MEff) of parasternal intercostal muscles. Gold standard assessment of diaphragm NMC requires using invasive techniques, limiting the utility of this procedure. Noninvasive NMC indices of parasternal intercostal muscles can be calculated using surface mechanomyography (sMMG<sub>para</sub>) and electromyography (sEMG<sub>para</sub>). However, the use of sMMG<sub>para</sub> as an inspiratory muscle mechanical output measure, and the relationships between sMMG<sub>para</sub>, sEMG<sub>para</sub>, and simultaneous invasive and noninvasive pressure measurements have not previously been evaluated. sEMG<sub>para</sub>, sMMG<sub>para</sub>, and both invasive and noninvasive measurements of pressures were recorded in twelve healthy subjects during an inspiratory loading protocol. The ratios of sMMG<sub>para</sub> to sEMG<sub>para</sub>, which provided muscle-specific noninvasive NMC indices of parasternal intercostal muscles, showed nonsignificant changes with increasing load, since the relationships between sMMG<sub>para</sub> and sEMG<sub>para</sub> were linear (R<sup>2</sup> = 0.85 (0.75–0.9)). The ratios of mouth pressure (P<sub>mo</sub>) to sEMG<sub>para</sub> and sMMG<sub>para</sub> were also proposed as noninvasive indices of parasternal intercostal muscle NMC and MEff, respectively. These indices, similar to the analogous indices calculated using invasive transdiaphragmatic and esophageal pressures, showed nonsignificant changes during threshold loading, since the relationships between P<sub>mo</sub> and both sEMG<sub>para</sub> (R<sup>2</sup> = 0.84 (0.77–0.93)) and sMMG<sub>para</sub> (R<sup>2</sup> = 0.89 (0.85–0.91)) were linear. The proposed noninvasive NMC and MEff indices of parasternal intercostal muscles may be of potential clinical value, particularly for the regular assessment of patients with disordered respiratory mechanics using noninvasive wearable and wireless devices.https://www.mdpi.com/1424-8220/21/5/1781inspiratory threshold loadingneuromechanical couplingparasternal intercostal musclesrespiratory pressuresurface electromyographysurface mechanomyography |
| spellingShingle | Manuel Lozano-García Luis Estrada-Petrocelli Abel Torres Gerrard F. Rafferty John Moxham Caroline J. Jolley Raimon Jané Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold Loading Sensors inspiratory threshold loading neuromechanical coupling parasternal intercostal muscles respiratory pressure surface electromyography surface mechanomyography |
| title | Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold Loading |
| title_full | Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold Loading |
| title_fullStr | Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold Loading |
| title_full_unstemmed | Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold Loading |
| title_short | Noninvasive Assessment of Neuromechanical Coupling and Mechanical Efficiency of Parasternal Intercostal Muscle during Inspiratory Threshold Loading |
| title_sort | noninvasive assessment of neuromechanical coupling and mechanical efficiency of parasternal intercostal muscle during inspiratory threshold loading |
| topic | inspiratory threshold loading neuromechanical coupling parasternal intercostal muscles respiratory pressure surface electromyography surface mechanomyography |
| url | https://www.mdpi.com/1424-8220/21/5/1781 |
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