Research development on gut microbiota and vulnerable atherosclerotic plaque
The relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of gut microbiota and its metabolites on inducing the formation of vulnerable atherosclerotic plaque, and to discuss the effect of...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024012179 |
| _version_ | 1797267823828926464 |
|---|---|
| author | Shujiao Zheng Zuheng Liu Haiyue Liu Jie Ying Lim Dolly Wong Hui Li Shaofeng Zhang Fang Luo Xiujing Wang Changqing Sun Rong Tang Wuyang Zheng Qiang Xie |
| author_facet | Shujiao Zheng Zuheng Liu Haiyue Liu Jie Ying Lim Dolly Wong Hui Li Shaofeng Zhang Fang Luo Xiujing Wang Changqing Sun Rong Tang Wuyang Zheng Qiang Xie |
| author_sort | Shujiao Zheng |
| collection | DOAJ |
| description | The relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of gut microbiota and its metabolites on inducing the formation of vulnerable atherosclerotic plaque, and to discuss the effect of intestinal metabolites, including trimethylamine-N-oxide (TMAO), lipopolysaccharide (LPS), phenylacetylglutamine (PAG), short-chain fatty acids (SCFAs) on plaque stability. Finally, we include the impact of gut microbiota and its metabolites on plaque stability, to propose a new therapeutic direction for coronary heart disease. Gut microbiota regulation intervenes the progress of arteriosclerosis, especially on coronary atherosclerosis, by avoiding or reducing the formation of vulnerable plaque, to lower the morbidity rate of myocardial infarction. |
| first_indexed | 2024-03-08T00:23:05Z |
| format | Article |
| id | doaj.art-9d7ae91e5e634e70be925da9dcbc9ae7 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-25T01:22:43Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-9d7ae91e5e634e70be925da9dcbc9ae72024-03-09T09:25:15ZengElsevierHeliyon2405-84402024-02-01104e25186Research development on gut microbiota and vulnerable atherosclerotic plaqueShujiao Zheng0Zuheng Liu1Haiyue Liu2Jie Ying Lim3Dolly Wong Hui Li4Shaofeng Zhang5Fang Luo6Xiujing Wang7Changqing Sun8Rong Tang9Wuyang Zheng10Qiang Xie11The School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaXiamen Key Laboratory of Genetic Testing, The Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, China; Corresponding author. The School of Clinical Medicine, Fujian Medical University, Fuzhou, 350108, China.The relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of gut microbiota and its metabolites on inducing the formation of vulnerable atherosclerotic plaque, and to discuss the effect of intestinal metabolites, including trimethylamine-N-oxide (TMAO), lipopolysaccharide (LPS), phenylacetylglutamine (PAG), short-chain fatty acids (SCFAs) on plaque stability. Finally, we include the impact of gut microbiota and its metabolites on plaque stability, to propose a new therapeutic direction for coronary heart disease. Gut microbiota regulation intervenes the progress of arteriosclerosis, especially on coronary atherosclerosis, by avoiding or reducing the formation of vulnerable plaque, to lower the morbidity rate of myocardial infarction.http://www.sciencedirect.com/science/article/pii/S2405844024012179AtherosclerosisGut microbiotaBacterial metabolitesVulnerable plaqueAcute coronary syndrome |
| spellingShingle | Shujiao Zheng Zuheng Liu Haiyue Liu Jie Ying Lim Dolly Wong Hui Li Shaofeng Zhang Fang Luo Xiujing Wang Changqing Sun Rong Tang Wuyang Zheng Qiang Xie Research development on gut microbiota and vulnerable atherosclerotic plaque Heliyon Atherosclerosis Gut microbiota Bacterial metabolites Vulnerable plaque Acute coronary syndrome |
| title | Research development on gut microbiota and vulnerable atherosclerotic plaque |
| title_full | Research development on gut microbiota and vulnerable atherosclerotic plaque |
| title_fullStr | Research development on gut microbiota and vulnerable atherosclerotic plaque |
| title_full_unstemmed | Research development on gut microbiota and vulnerable atherosclerotic plaque |
| title_short | Research development on gut microbiota and vulnerable atherosclerotic plaque |
| title_sort | research development on gut microbiota and vulnerable atherosclerotic plaque |
| topic | Atherosclerosis Gut microbiota Bacterial metabolites Vulnerable plaque Acute coronary syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024012179 |
| work_keys_str_mv | AT shujiaozheng researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT zuhengliu researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT haiyueliu researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT jieyinglim researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT dollywonghuili researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT shaofengzhang researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT fangluo researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT xiujingwang researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT changqingsun researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT rongtang researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT wuyangzheng researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque AT qiangxie researchdevelopmentongutmicrobiotaandvulnerableatheroscleroticplaque |