Calreticulin and the Heart
Calreticulin is an endoplasmic Ca<sup>2+</sup> binding protein and molecular chaperone. As a cardiac embryonic gene, calreticulin is essential for heart development. The protein supports Ca<sup>2+</sup>-dependent signaling events that are critical to cardiomyocyte differentia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/11/1722 |
| _version_ | 1797493864232124416 |
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| author | Jody Groenendyk Wen-An Wang Alison Robinson Marek Michalak |
| author_facet | Jody Groenendyk Wen-An Wang Alison Robinson Marek Michalak |
| author_sort | Jody Groenendyk |
| collection | DOAJ |
| description | Calreticulin is an endoplasmic Ca<sup>2+</sup> binding protein and molecular chaperone. As a cardiac embryonic gene, calreticulin is essential for heart development. The protein supports Ca<sup>2+</sup>-dependent signaling events that are critical to cardiomyocyte differentiation and cardiogenesis. The increased expression of calreticulin and endoplasmic reticulum/sarcoplasmic reticulum Ca<sup>2+</sup> capacity produces cardiomyocytes with enhanced efficiency, and detrimental mechanical stretching of cardiac fibroblasts, leading to cardiac pathology. Deletion of the calreticulin gene in adult cardiomyocytes results in left ventricle dilation, an impaired electrocardiogram, and heart failure. These observations indicate that a well-adjusted endoplasmic reticulum and calreticulin-dependent Ca<sup>2+</sup> pool in cardiomyocytes are critical for the maintenance of proper cardiac function. |
| first_indexed | 2024-03-10T01:26:05Z |
| format | Article |
| id | doaj.art-9d7bf7d70d934b4786785f928cbf1556 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:26:05Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9d7bf7d70d934b4786785f928cbf15562023-11-23T13:51:43ZengMDPI AGCells2073-44092022-05-011111172210.3390/cells11111722Calreticulin and the HeartJody Groenendyk0Wen-An Wang1Alison Robinson2Marek Michalak3Department of Biochemistry, University of Alberta, Edmonton, AB T6G 1H7, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 1H7, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 1H7, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 1H7, CanadaCalreticulin is an endoplasmic Ca<sup>2+</sup> binding protein and molecular chaperone. As a cardiac embryonic gene, calreticulin is essential for heart development. The protein supports Ca<sup>2+</sup>-dependent signaling events that are critical to cardiomyocyte differentiation and cardiogenesis. The increased expression of calreticulin and endoplasmic reticulum/sarcoplasmic reticulum Ca<sup>2+</sup> capacity produces cardiomyocytes with enhanced efficiency, and detrimental mechanical stretching of cardiac fibroblasts, leading to cardiac pathology. Deletion of the calreticulin gene in adult cardiomyocytes results in left ventricle dilation, an impaired electrocardiogram, and heart failure. These observations indicate that a well-adjusted endoplasmic reticulum and calreticulin-dependent Ca<sup>2+</sup> pool in cardiomyocytes are critical for the maintenance of proper cardiac function.https://www.mdpi.com/2073-4409/11/11/1722endoplasmic reticulumchaperonecalreticulincalcium |
| spellingShingle | Jody Groenendyk Wen-An Wang Alison Robinson Marek Michalak Calreticulin and the Heart Cells endoplasmic reticulum chaperone calreticulin calcium |
| title | Calreticulin and the Heart |
| title_full | Calreticulin and the Heart |
| title_fullStr | Calreticulin and the Heart |
| title_full_unstemmed | Calreticulin and the Heart |
| title_short | Calreticulin and the Heart |
| title_sort | calreticulin and the heart |
| topic | endoplasmic reticulum chaperone calreticulin calcium |
| url | https://www.mdpi.com/2073-4409/11/11/1722 |
| work_keys_str_mv | AT jodygroenendyk calreticulinandtheheart AT wenanwang calreticulinandtheheart AT alisonrobinson calreticulinandtheheart AT marekmichalak calreticulinandtheheart |