Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia
Quantitative electroencephalography (QEEG) has proven useful in predicting the response to various treatments, but, until now, no study has investigated changes in functional connectivity using QEEG following a lifestyle intervention program. We aimed to investigate neurophysiological changes in QEE...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.892590/full |
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| author | Hee Kyung Park Hee Kyung Park Seong Hye Choi SeonMyeong Kim Ukeob Park Seung Wan Kang Seung Wan Kang Jee Hyang Jeong So Young Moon Chang Hyung Hong Hong-Sun Song Buong-O Chun Sun Min Lee Muncheong Choi Kyung Won Park Byeong C. Kim Soo Hyun Cho Hae Ri Na Yoo Kyoung Park Yoo Kyoung Park |
| author_facet | Hee Kyung Park Hee Kyung Park Seong Hye Choi SeonMyeong Kim Ukeob Park Seung Wan Kang Seung Wan Kang Jee Hyang Jeong So Young Moon Chang Hyung Hong Hong-Sun Song Buong-O Chun Sun Min Lee Muncheong Choi Kyung Won Park Byeong C. Kim Soo Hyun Cho Hae Ri Na Yoo Kyoung Park Yoo Kyoung Park |
| author_sort | Hee Kyung Park |
| collection | DOAJ |
| description | Quantitative electroencephalography (QEEG) has proven useful in predicting the response to various treatments, but, until now, no study has investigated changes in functional connectivity using QEEG following a lifestyle intervention program. We aimed to investigate neurophysiological changes in QEEG after a 24-week multidomain lifestyle intervention program in the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN). Participants without dementia and with at least one modifiable dementia risk factor, aged 60–79 years, were randomly assigned to the facility-based multidomain intervention (FMI) (n = 51), the home-based multidomain intervention (HMI) (n = 51), and the control group (n = 50). The analysis of this study included data from 44, 49, and 34 participants who underwent EEG at baseline and at the end of the study in the FMI, HMI, and control groups, respectively. The spectrum power and power ratio of EEG were calculated. Source cortical current density and functional connectivity were estimated by standardized low-resolution brain electromagnetic tomography. Participants who received the intervention showed increases in the power of the beta1 and beta3 bands and in the imaginary part of coherence of the alpha1 band compared to the control group. Decreases in the characteristic path lengths of the alpha1 band in the right supramarginal gyrus and right rostral middle frontal cortex were observed in those who received the intervention. This study showed positive biological changes, including increased functional connectivity and higher global efficiency in QEEG after a multidomain lifestyle intervention.Clinical trial registration[https://clinicaltrials.gov/ct2/show/NCT03980392] identifier [NCT03980392]. |
| first_indexed | 2024-04-11T16:45:21Z |
| format | Article |
| id | doaj.art-9d7c81fad8714466b943600b41bbba56 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T16:45:21Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-9d7c81fad8714466b943600b41bbba562022-12-22T04:13:35ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-10-011410.3389/fnagi.2022.892590892590Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementiaHee Kyung Park0Hee Kyung Park1Seong Hye Choi2SeonMyeong Kim3Ukeob Park4Seung Wan Kang5Seung Wan Kang6Jee Hyang Jeong7So Young Moon8Chang Hyung Hong9Hong-Sun Song10Buong-O Chun11Sun Min Lee12Muncheong Choi13Kyung Won Park14Byeong C. Kim15Soo Hyun Cho16Hae Ri Na17Yoo Kyoung Park18Yoo Kyoung Park19Department of Neurology, Ewha Womans University School of Medicine, Seoul, South KoreaDepartment of Mental Health Care of Older People, Division of Psychiatry, University College London, London, United KingdomDepartment of Neurology, Inha University School of Medicine, Incheon, South KoreaiMediSync Inc., Seoul, South KoreaiMediSync Inc., Seoul, South KoreaiMediSync Inc., Seoul, South KoreaData Center for Korean EEG, College of Nursing, Seoul National University, Seoul, South KoreaDepartment of Neurology, Ewha Womans University School of Medicine, Seoul, South KoreaDepartment of Neurology, Ajou University School of Medicine, Suwon, South KoreaDepartment of Psychiatry, Ajou University School of Medicine, Suwon, South KoreaDepartment of Sports Sciences, Korea Institute of Sports Science, Seoul, South KoreaGraduate School of Physical Education, College of Arts and Physical Education, Myongji University, Seoul, South KoreaDepartment of Neurology, Ajou University School of Medicine, Suwon, South Korea0Department of Sports and Health Science, Shinhan University, Uijeongbu-si, South Korea1Department of Neurology, Dong-A University College of Medicine, Busan, South Korea2Department of Neurology, Chonnam National University Medical School and Hospital, Gwangju, South Korea2Department of Neurology, Chonnam National University Medical School and Hospital, Gwangju, South Korea3Department of Neurology, Bobath Memorial Hospital, Seongnam, South Korea4Department of Medical Nutrition, Graduate School of East-West Medical Nutrition, Kyung Hee University, Yongin, South Korea5Department of Food Innovation and Health, Graduate School of East-West Medical Nutrition, Kyung Hee University, Yongin, South KoreaQuantitative electroencephalography (QEEG) has proven useful in predicting the response to various treatments, but, until now, no study has investigated changes in functional connectivity using QEEG following a lifestyle intervention program. We aimed to investigate neurophysiological changes in QEEG after a 24-week multidomain lifestyle intervention program in the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN). Participants without dementia and with at least one modifiable dementia risk factor, aged 60–79 years, were randomly assigned to the facility-based multidomain intervention (FMI) (n = 51), the home-based multidomain intervention (HMI) (n = 51), and the control group (n = 50). The analysis of this study included data from 44, 49, and 34 participants who underwent EEG at baseline and at the end of the study in the FMI, HMI, and control groups, respectively. The spectrum power and power ratio of EEG were calculated. Source cortical current density and functional connectivity were estimated by standardized low-resolution brain electromagnetic tomography. Participants who received the intervention showed increases in the power of the beta1 and beta3 bands and in the imaginary part of coherence of the alpha1 band compared to the control group. Decreases in the characteristic path lengths of the alpha1 band in the right supramarginal gyrus and right rostral middle frontal cortex were observed in those who received the intervention. This study showed positive biological changes, including increased functional connectivity and higher global efficiency in QEEG after a multidomain lifestyle intervention.Clinical trial registration[https://clinicaltrials.gov/ct2/show/NCT03980392] identifier [NCT03980392].https://www.frontiersin.org/articles/10.3389/fnagi.2022.892590/fullcognitive impairmentbiomarkersquantitative electroencephalographydementiamultidomain intervention |
| spellingShingle | Hee Kyung Park Hee Kyung Park Seong Hye Choi SeonMyeong Kim Ukeob Park Seung Wan Kang Seung Wan Kang Jee Hyang Jeong So Young Moon Chang Hyung Hong Hong-Sun Song Buong-O Chun Sun Min Lee Muncheong Choi Kyung Won Park Byeong C. Kim Soo Hyun Cho Hae Ri Na Yoo Kyoung Park Yoo Kyoung Park Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia Frontiers in Aging Neuroscience cognitive impairment biomarkers quantitative electroencephalography dementia multidomain intervention |
| title | Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia |
| title_full | Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia |
| title_fullStr | Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia |
| title_full_unstemmed | Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia |
| title_short | Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia |
| title_sort | functional brain changes using electroencephalography after a 24 week multidomain intervention program to prevent dementia |
| topic | cognitive impairment biomarkers quantitative electroencephalography dementia multidomain intervention |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.892590/full |
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