Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia
Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Human Pathology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772736X23000233 |
| _version_ | 1797690874053787648 |
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| author | Amina Anwar Zena Chahine Dava Piecoro Melissa Kesler Ayman Qasrawi |
| author_facet | Amina Anwar Zena Chahine Dava Piecoro Melissa Kesler Ayman Qasrawi |
| author_sort | Amina Anwar |
| collection | DOAJ |
| description | Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who one succumbed to illness despite treatment with multiple agents. These cases emphasize the difficulty of diagnosis and treatment of this rare condition. |
| first_indexed | 2024-03-12T02:05:23Z |
| format | Article |
| id | doaj.art-9d7e0917f6ab4bf6b9b153c5b64a404e |
| institution | Directory Open Access Journal |
| issn | 2772-736X |
| language | English |
| last_indexed | 2024-03-12T02:05:23Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology Reports |
| spelling | doaj.art-9d7e0917f6ab4bf6b9b153c5b64a404e2023-09-07T04:45:13ZengElsevierHuman Pathology Reports2772-736X2023-09-0133300713Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopeniaAmina Anwar0Zena Chahine1Dava Piecoro2Melissa Kesler3Ayman Qasrawi4University of Kentucky College of Medicine, University of Kentucky, Lexington KY 40536, United StatesDepartment of Internal Medicine, Division of Hematology, University of Kentucky, Lexington KY 40536, United States; Corresponding author at: Department of Internal Medicine, Division of Hematology, University of Kentucky, 800 Rose Street Suite CC-402, Lexington, KY 40536, United States.Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, United StatesDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, United StatesDepartment of Internal Medicine, Division of Hematology, University of Kentucky, Lexington KY 40536, United StatesAcquired amegakaryocytic thrombocytopenia (AAMT) is a rare hematological disorder characterized by prolonged, severe thrombocytopenia, and reduced megakaryocytes on otherwise normal bone marrow biopsy. We report three cases of which two ultimately responded to treatment with eltrombopag, and one who one succumbed to illness despite treatment with multiple agents. These cases emphasize the difficulty of diagnosis and treatment of this rare condition.http://www.sciencedirect.com/science/article/pii/S2772736X23000233Platelet disorderDiminished or absent megakaryopoiesisRare hematological condition |
| spellingShingle | Amina Anwar Zena Chahine Dava Piecoro Melissa Kesler Ayman Qasrawi Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia Human Pathology Reports Platelet disorder Diminished or absent megakaryopoiesis Rare hematological condition |
| title | Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia |
| title_full | Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia |
| title_fullStr | Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia |
| title_full_unstemmed | Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia |
| title_short | Hard to find and tricky to treat: A case series of acquired amegakaryocytic thrombocytopenia |
| title_sort | hard to find and tricky to treat a case series of acquired amegakaryocytic thrombocytopenia |
| topic | Platelet disorder Diminished or absent megakaryopoiesis Rare hematological condition |
| url | http://www.sciencedirect.com/science/article/pii/S2772736X23000233 |
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