Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps
The complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) generates a spectrum of phenotypes with a wide variety of inflammatory states. We enrolled 44 very-likely-to-be type 2 CRSwNP patients in order to evaluate the load of inflammation and to analyze human interleukins in n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/8/1251 |
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| author | Eugenio De Corso Silvia Baroni Stefano Settimi Maria Elisabetta Onori Rodolfo Francesco Mastrapasqua Eliana Troiani Giacomo Moretti Donatella Lucchetti Marco Corbò Claudio Montuori Alessandro Cantiani Davide Paolo Porru Simone Lo Verde Giuseppe Alberto Di Bella Cristiano Caruso Jacopo Galli |
| author_facet | Eugenio De Corso Silvia Baroni Stefano Settimi Maria Elisabetta Onori Rodolfo Francesco Mastrapasqua Eliana Troiani Giacomo Moretti Donatella Lucchetti Marco Corbò Claudio Montuori Alessandro Cantiani Davide Paolo Porru Simone Lo Verde Giuseppe Alberto Di Bella Cristiano Caruso Jacopo Galli |
| author_sort | Eugenio De Corso |
| collection | DOAJ |
| description | The complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) generates a spectrum of phenotypes with a wide variety of inflammatory states. We enrolled 44 very-likely-to-be type 2 CRSwNP patients in order to evaluate the load of inflammation and to analyze human interleukins in nasal secretion. Clinical data were collected to evaluate the severity of the disease. High levels of IL-5, IL-4, IL-6, and IL-33 were detected in all type 2 CRSwNP patients. By analyzing type 2 cytokine profiles and local eosinophil count, we identified two coherent clusters: the first was characterized by high levels of IL-4, IL-5, IL-6, and a high-grade eosinophil count (type 2-high); the second had lower levels of cytokines and poor or absent eosinophilic inflammation (type-2 low). IL-5 levels were significantly higher within the type 2 cytokine and it was the most reliable biomarker for differentiating the two clusters. In type 2-high inflammatory profile clinical scores, the mean number of previous surgeries and need for systemic corticosteroids were significantly higher compared to type 2-low. Our research demonstrated the potential role of type 2 biomarkers, and in particular, of IL-5 in identifying patients with a more severe phenotype based on a high inflammatory load. |
| first_indexed | 2024-03-09T04:15:14Z |
| format | Article |
| id | doaj.art-9d7e61eb93f1464b92dd409aa173393e |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T04:15:14Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-9d7e61eb93f1464b92dd409aa173393e2023-12-03T13:55:57ZengMDPI AGJournal of Personalized Medicine2075-44262022-07-01128125110.3390/jpm12081251Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal PolypsEugenio De Corso0Silvia Baroni1Stefano Settimi2Maria Elisabetta Onori3Rodolfo Francesco Mastrapasqua4Eliana Troiani5Giacomo Moretti6Donatella Lucchetti7Marco Corbò8Claudio Montuori9Alessandro Cantiani10Davide Paolo Porru11Simone Lo Verde12Giuseppe Alberto Di Bella13Cristiano Caruso14Jacopo Galli15Unit of Otorhinolaryngology and Head-Neck Surgery, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, ItalyUnit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, ItalyUnit of Otorhinolaryngology and Head-Neck Surgery, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Head-Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Head-Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Head-Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Head-Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Head-Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Head-Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Head-Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Medical and Surgical Sciences, Digestive Disease Center, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, ItalyUnit of Otorhinolaryngology and Head-Neck Surgery, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, ItalyThe complex pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) generates a spectrum of phenotypes with a wide variety of inflammatory states. We enrolled 44 very-likely-to-be type 2 CRSwNP patients in order to evaluate the load of inflammation and to analyze human interleukins in nasal secretion. Clinical data were collected to evaluate the severity of the disease. High levels of IL-5, IL-4, IL-6, and IL-33 were detected in all type 2 CRSwNP patients. By analyzing type 2 cytokine profiles and local eosinophil count, we identified two coherent clusters: the first was characterized by high levels of IL-4, IL-5, IL-6, and a high-grade eosinophil count (type 2-high); the second had lower levels of cytokines and poor or absent eosinophilic inflammation (type-2 low). IL-5 levels were significantly higher within the type 2 cytokine and it was the most reliable biomarker for differentiating the two clusters. In type 2-high inflammatory profile clinical scores, the mean number of previous surgeries and need for systemic corticosteroids were significantly higher compared to type 2-low. Our research demonstrated the potential role of type 2 biomarkers, and in particular, of IL-5 in identifying patients with a more severe phenotype based on a high inflammatory load.https://www.mdpi.com/2075-4426/12/8/1251chronic rhinosinusitiseosinophilic rhinitisnasal polyposisbiomarkermedical therapy of chronic rhinosinusitisdisease severity |
| spellingShingle | Eugenio De Corso Silvia Baroni Stefano Settimi Maria Elisabetta Onori Rodolfo Francesco Mastrapasqua Eliana Troiani Giacomo Moretti Donatella Lucchetti Marco Corbò Claudio Montuori Alessandro Cantiani Davide Paolo Porru Simone Lo Verde Giuseppe Alberto Di Bella Cristiano Caruso Jacopo Galli Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps Journal of Personalized Medicine chronic rhinosinusitis eosinophilic rhinitis nasal polyposis biomarker medical therapy of chronic rhinosinusitis disease severity |
| title | Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps |
| title_full | Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps |
| title_fullStr | Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps |
| title_full_unstemmed | Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps |
| title_short | Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps |
| title_sort | sinonasal biomarkers defining type 2 high and type 2 low inflammation in chronic rhinosinusitis with nasal polyps |
| topic | chronic rhinosinusitis eosinophilic rhinitis nasal polyposis biomarker medical therapy of chronic rhinosinusitis disease severity |
| url | https://www.mdpi.com/2075-4426/12/8/1251 |
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