Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse
Phosphoinositides, together with the phospholipids phosphatidylserine and phosphatidic acid, are important components of the plasma membrane acting as second messengers that, with diacylglycerol, regulate a diverse range of signaling events converting extracellular changes into cellular responses. L...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00700/full |
| _version_ | 1819013269451440128 |
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| author | Christian M. Gawden-Bone Gillian M. Griffiths |
| author_facet | Christian M. Gawden-Bone Gillian M. Griffiths |
| author_sort | Christian M. Gawden-Bone |
| collection | DOAJ |
| description | Phosphoinositides, together with the phospholipids phosphatidylserine and phosphatidic acid, are important components of the plasma membrane acting as second messengers that, with diacylglycerol, regulate a diverse range of signaling events converting extracellular changes into cellular responses. Local changes in their distribution and membrane charge on the inner leaflet of the plasma membrane play important roles in immune cell function. Here we discuss their distribution and regulators highlighting the importance of membrane changes across the immune synapse on the cytoskeleton and the impact on the function of cytotoxic T lymphocytes. |
| first_indexed | 2024-12-21T01:57:16Z |
| format | Article |
| id | doaj.art-9d7e7ad0c3f94100bb553c17995015fe |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T01:57:16Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9d7e7ad0c3f94100bb553c17995015fe2022-12-21T19:19:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00700433969Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune SynapseChristian M. Gawden-BoneGillian M. GriffithsPhosphoinositides, together with the phospholipids phosphatidylserine and phosphatidic acid, are important components of the plasma membrane acting as second messengers that, with diacylglycerol, regulate a diverse range of signaling events converting extracellular changes into cellular responses. Local changes in their distribution and membrane charge on the inner leaflet of the plasma membrane play important roles in immune cell function. Here we discuss their distribution and regulators highlighting the importance of membrane changes across the immune synapse on the cytoskeleton and the impact on the function of cytotoxic T lymphocytes.https://www.frontiersin.org/article/10.3389/fimmu.2019.00700/fullT cellscytotoxic T lymphocytes (CTLs)phospholipidsphosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)diacylglycerol (DAG)phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) |
| spellingShingle | Christian M. Gawden-Bone Gillian M. Griffiths Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse Frontiers in Immunology T cells cytotoxic T lymphocytes (CTLs) phospholipids phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) diacylglycerol (DAG) phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) |
| title | Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse |
| title_full | Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse |
| title_fullStr | Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse |
| title_full_unstemmed | Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse |
| title_short | Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse |
| title_sort | phospholipids pulling back the actin curtain for granule delivery to the immune synapse |
| topic | T cells cytotoxic T lymphocytes (CTLs) phospholipids phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) diacylglycerol (DAG) phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00700/full |
| work_keys_str_mv | AT christianmgawdenbone phospholipidspullingbacktheactincurtainforgranuledeliverytotheimmunesynapse AT gillianmgriffiths phospholipidspullingbacktheactincurtainforgranuledeliverytotheimmunesynapse |