Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease
Background: We aimed to evaluate the performance of serum cystatin C-based equations in calculating the glomerular filtration rate (GFR) in patients with varying stages of chronic kidney disease (CKD). Methods: Serum cystatin C and creatinine levels were measured in 615 CKD patients. The CKD stage w...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2014-03-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913213000971 |
| _version_ | 1818542011288911872 |
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| author | Hee Sun Lee Harin Rhee Eun Young Seong Dong Won Lee Soo Bong Lee Ihm Soo Kwak |
| author_facet | Hee Sun Lee Harin Rhee Eun Young Seong Dong Won Lee Soo Bong Lee Ihm Soo Kwak |
| author_sort | Hee Sun Lee |
| collection | DOAJ |
| description | Background: We aimed to evaluate the performance of serum cystatin C-based equations in calculating the glomerular filtration rate (GFR) in patients with varying stages of chronic kidney disease (CKD).
Methods: Serum cystatin C and creatinine levels were measured in 615 CKD patients. The CKD stage was determined by the creatinine-based estimated GFR (eGFR) equation using the four-variable abbreviated Modification of Diet in Renal Disease equation suggested by the Kidney Disease Outcome Quality Initiative with the addition of a coefficient applicable to Korean populations (K-aMDRD). In each CKD stage, the ratio of serum cystatin C to creatinine was calculated and six different cystatin C-based equations were used to estimate GFR. Cystatin C-based eGFR and aMDRD eGFR values were compared using the paired t test, Pearson correlation test, and the Bland–Altman plot.
Results: The mean age of patients was 53.21±14.45 years; of the 615 patients, 346 were male. The serum cystatin C-to-creatinine ratio was inversely correlated with the CKD stage. Compared with the K-aMDRD values, the results of the Hoek, Filler, and Le Bricon’s cystatin C-based eGFR equations were lower in CKD Stages 1–3 and higher in Stages 4 and 5. However, the results of the Orebro-cystatin (Gentian) equation [GFR=100/ScytC (mL/minute/1.73 m2) – 14] were similar to those of the K-aMDRD equation in CKD Stages 4 and 5 (15.44±9.45 vs. 15.17±9.05 mL/minute/1.73 m2, respectively; P=0.722; bias=0.27±8.87).
Conclusion: The eGFRs obtained from the six cystatin C-based equations differed widely. Therefore, further studies are required to determine the most accurate equation to estimate GFR in Koreans with CKD. |
| first_indexed | 2024-12-11T22:16:35Z |
| format | Article |
| id | doaj.art-9d7f063f7e28431294830ba3435931fa |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-11T22:16:35Z |
| publishDate | 2014-03-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-9d7f063f7e28431294830ba3435931fa2022-12-22T00:48:35ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322014-03-01331455110.1016/j.krcp.2013.11.001Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney diseaseHee Sun Lee0Harin Rhee1Eun Young Seong2Dong Won Lee3Soo Bong Lee4Ihm Soo Kwak5Department of Internal Medicine, Youngdo Hospital, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaBackground: We aimed to evaluate the performance of serum cystatin C-based equations in calculating the glomerular filtration rate (GFR) in patients with varying stages of chronic kidney disease (CKD). Methods: Serum cystatin C and creatinine levels were measured in 615 CKD patients. The CKD stage was determined by the creatinine-based estimated GFR (eGFR) equation using the four-variable abbreviated Modification of Diet in Renal Disease equation suggested by the Kidney Disease Outcome Quality Initiative with the addition of a coefficient applicable to Korean populations (K-aMDRD). In each CKD stage, the ratio of serum cystatin C to creatinine was calculated and six different cystatin C-based equations were used to estimate GFR. Cystatin C-based eGFR and aMDRD eGFR values were compared using the paired t test, Pearson correlation test, and the Bland–Altman plot. Results: The mean age of patients was 53.21±14.45 years; of the 615 patients, 346 were male. The serum cystatin C-to-creatinine ratio was inversely correlated with the CKD stage. Compared with the K-aMDRD values, the results of the Hoek, Filler, and Le Bricon’s cystatin C-based eGFR equations were lower in CKD Stages 1–3 and higher in Stages 4 and 5. However, the results of the Orebro-cystatin (Gentian) equation [GFR=100/ScytC (mL/minute/1.73 m2) – 14] were similar to those of the K-aMDRD equation in CKD Stages 4 and 5 (15.44±9.45 vs. 15.17±9.05 mL/minute/1.73 m2, respectively; P=0.722; bias=0.27±8.87). Conclusion: The eGFRs obtained from the six cystatin C-based equations differed widely. Therefore, further studies are required to determine the most accurate equation to estimate GFR in Koreans with CKD.http://www.sciencedirect.com/science/article/pii/S2211913213000971Chronic kidney diseaseCystatin CEstimated glomerular filtration rateSerum creatinine |
| spellingShingle | Hee Sun Lee Harin Rhee Eun Young Seong Dong Won Lee Soo Bong Lee Ihm Soo Kwak Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease Kidney Research and Clinical Practice Chronic kidney disease Cystatin C Estimated glomerular filtration rate Serum creatinine |
| title | Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease |
| title_full | Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease |
| title_fullStr | Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease |
| title_full_unstemmed | Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease |
| title_short | Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease |
| title_sort | comparison of glomerular filtration rates calculated by different serum cystatin c based equations in patients with chronic kidney disease |
| topic | Chronic kidney disease Cystatin C Estimated glomerular filtration rate Serum creatinine |
| url | http://www.sciencedirect.com/science/article/pii/S2211913213000971 |
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