<i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges
A newfound appreciation for the benefits of herbal treatments has emerged in recent decades. However, herbal medication production still needs to establish standardized protocols that adhere to strict guidelines for quality assurance and risk minimization. Although the therapeutic effects of herbal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/3/409 |
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| author | Hlengwa N. Masilela C. Mtambo T. R. Sithole S. Naidoo S. Machaba K. E. Shabalala S. C. Ntamo Y. Dludla P. V. Milase R. N. |
| author_facet | Hlengwa N. Masilela C. Mtambo T. R. Sithole S. Naidoo S. Machaba K. E. Shabalala S. C. Ntamo Y. Dludla P. V. Milase R. N. |
| author_sort | Hlengwa N. |
| collection | DOAJ |
| description | A newfound appreciation for the benefits of herbal treatments has emerged in recent decades. However, herbal medication production still needs to establish standardized protocols that adhere to strict guidelines for quality assurance and risk minimization. Although the therapeutic effects of herbal medicines are extensive, the risk of herb–drug interactions remains a serious concern, limiting their use. Therefore, a robust, well-established liver model that can fully represent the liver tissue is required to study potential herb–drug interactions to ensure herbal medicines’ safe and effective use. In light of this, this mini review investigates the existing <i>in vitro</i> liver models applicable to detecting herbal medicines’ toxicity and other pharmacological targets. This article analyzes the benefits and drawbacks of existing <i>in vitro</i> liver cell models. To maintain relevance and effectively express the offered research, a systematic strategy was employed to search for and include all discussed studies. In brief, from 1985 to December 2022, the phrases “liver models”, “herb–drug interaction”, “herbal medicine”, “cytochrome P450”, “drug transporters pharmacokinetics”, and “pharmacodynamics” were combined to search the electronic databases PubMed, ScienceDirect, and the Cochrane Library. |
| first_indexed | 2024-03-11T06:03:25Z |
| format | Article |
| id | doaj.art-9d7f56de9954421fae6d8751f5f1c0e8 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T06:03:25Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-9d7f56de9954421fae6d8751f5f1c0e82023-11-17T13:12:24ZengMDPI AGPharmaceuticals1424-82472023-03-0116340910.3390/ph16030409<i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and ChallengesHlengwa N.0Masilela C.1Mtambo T. R.2Sithole S.3Naidoo S.4Machaba K. E.5Shabalala S. C.6Ntamo Y.7Dludla P. V.8Milase R. N.9Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry, North-West University, Mafikeng 2745, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaBiomedical Research and Innovation Platform and South African Medical Research Council, Cape Town 7505, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaDepartment of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaA newfound appreciation for the benefits of herbal treatments has emerged in recent decades. However, herbal medication production still needs to establish standardized protocols that adhere to strict guidelines for quality assurance and risk minimization. Although the therapeutic effects of herbal medicines are extensive, the risk of herb–drug interactions remains a serious concern, limiting their use. Therefore, a robust, well-established liver model that can fully represent the liver tissue is required to study potential herb–drug interactions to ensure herbal medicines’ safe and effective use. In light of this, this mini review investigates the existing <i>in vitro</i> liver models applicable to detecting herbal medicines’ toxicity and other pharmacological targets. This article analyzes the benefits and drawbacks of existing <i>in vitro</i> liver cell models. To maintain relevance and effectively express the offered research, a systematic strategy was employed to search for and include all discussed studies. In brief, from 1985 to December 2022, the phrases “liver models”, “herb–drug interaction”, “herbal medicine”, “cytochrome P450”, “drug transporters pharmacokinetics”, and “pharmacodynamics” were combined to search the electronic databases PubMed, ScienceDirect, and the Cochrane Library.https://www.mdpi.com/1424-8247/16/3/409herb–drug interactionshepatic modelshuman liver microsomesS9 liver fractionsprimary hepatocytesprecision liver slices |
| spellingShingle | Hlengwa N. Masilela C. Mtambo T. R. Sithole S. Naidoo S. Machaba K. E. Shabalala S. C. Ntamo Y. Dludla P. V. Milase R. N. <i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges Pharmaceuticals herb–drug interactions hepatic models human liver microsomes S9 liver fractions primary hepatocytes precision liver slices |
| title | <i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges |
| title_full | <i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges |
| title_fullStr | <i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges |
| title_full_unstemmed | <i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges |
| title_short | <i>In Vitro</i> Hepatic Models to Assess Herb–Drug Interactions: Approaches and Challenges |
| title_sort | i in vitro i hepatic models to assess herb drug interactions approaches and challenges |
| topic | herb–drug interactions hepatic models human liver microsomes S9 liver fractions primary hepatocytes precision liver slices |
| url | https://www.mdpi.com/1424-8247/16/3/409 |
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