Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial
Abstract Background Hidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochante...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-017-0625-9 |
| _version_ | 1798003987501285376 |
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| author | Jinlai Lei Binfei Zhang Yuxuan Cong Yan Zhuang Xing Wei Yahui Fu Wei Wei Pengfei Wang Shiming Wen Hai Huang Hu Wang Shuang Han Shuguang Liu Kun Zhang |
| author_facet | Jinlai Lei Binfei Zhang Yuxuan Cong Yan Zhuang Xing Wei Yahui Fu Wei Wei Pengfei Wang Shiming Wen Hai Huang Hu Wang Shuang Han Shuguang Liu Kun Zhang |
| author_sort | Jinlai Lei |
| collection | DOAJ |
| description | Abstract Background Hidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochanteric fracture. Methods A total of 77 patients with intertrochanteric fracture were enrolled in this randomized controlled study. Patients received either 200 mL (1 g) of TXA (n = 37) or normal-saline (NS) (n = 40) i.v. before hip surgery using proximal femoral nail anti-rotation (PFNA). Hemoglobin and hematocrit levels were measured preoperatively and postoperatively at day 1 and 3. Visible and hidden blood loss volumes were calculated at postoperative day 3. Results On postoperative day 3, the transfusion rate was significantly lower in the TXA group compared to the NS group, although mean hemoglobin and hematocrit levels were not significantly different between the two groups. However, the estimated hidden blood loss volume (210.09 ± 202.14 mL vs. 359.35 ± 290.12 mL; P < 0.05) and total blood loss volume (279.35 ± 209.11 mL vs. 417.89 ± 289.56 mL; P < 0.05) were significantly less in the TXA group compared to the NS group, respectively. Conclusion TXA significantly reduced postoperative hidden blood loss in patients with intertrochanteric fracture who underwent PFNA. (Registration number: ChiCTR-INR-16008134). |
| first_indexed | 2024-04-11T12:17:13Z |
| format | Article |
| id | doaj.art-9d822a6155bb4092ac56f3c488e9588e |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T12:17:13Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-9d822a6155bb4092ac56f3c488e9588e2022-12-22T04:24:16ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2017-08-011211610.1186/s13018-017-0625-9Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trialJinlai Lei0Binfei Zhang1Yuxuan Cong2Yan Zhuang3Xing Wei4Yahui Fu5Wei Wei6Pengfei Wang7Shiming Wen8Hai Huang9Hu Wang10Shuang Han11Shuguang Liu12Kun Zhang13Department of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterDepartment of Orthopaedic Trauma, Xi’an Honghui Hospital, Xi’an Jiaotong University Health Science CenterAbstract Background Hidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochanteric fracture. Methods A total of 77 patients with intertrochanteric fracture were enrolled in this randomized controlled study. Patients received either 200 mL (1 g) of TXA (n = 37) or normal-saline (NS) (n = 40) i.v. before hip surgery using proximal femoral nail anti-rotation (PFNA). Hemoglobin and hematocrit levels were measured preoperatively and postoperatively at day 1 and 3. Visible and hidden blood loss volumes were calculated at postoperative day 3. Results On postoperative day 3, the transfusion rate was significantly lower in the TXA group compared to the NS group, although mean hemoglobin and hematocrit levels were not significantly different between the two groups. However, the estimated hidden blood loss volume (210.09 ± 202.14 mL vs. 359.35 ± 290.12 mL; P < 0.05) and total blood loss volume (279.35 ± 209.11 mL vs. 417.89 ± 289.56 mL; P < 0.05) were significantly less in the TXA group compared to the NS group, respectively. Conclusion TXA significantly reduced postoperative hidden blood loss in patients with intertrochanteric fracture who underwent PFNA. (Registration number: ChiCTR-INR-16008134).http://link.springer.com/article/10.1186/s13018-017-0625-9Tranexamic acidHidden blood lossIntertrochanteric femoraFracturePFNARandomized controlled trial |
| spellingShingle | Jinlai Lei Binfei Zhang Yuxuan Cong Yan Zhuang Xing Wei Yahui Fu Wei Wei Pengfei Wang Shiming Wen Hai Huang Hu Wang Shuang Han Shuguang Liu Kun Zhang Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial Journal of Orthopaedic Surgery and Research Tranexamic acid Hidden blood loss Intertrochanteric femora Fracture PFNA Randomized controlled trial |
| title | Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial |
| title_full | Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial |
| title_fullStr | Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial |
| title_full_unstemmed | Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial |
| title_short | Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial |
| title_sort | tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with pfna a single center randomized controlled trial |
| topic | Tranexamic acid Hidden blood loss Intertrochanteric femora Fracture PFNA Randomized controlled trial |
| url | http://link.springer.com/article/10.1186/s13018-017-0625-9 |
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