Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials
Ferrous sulfate is a commonly used iron supplement for the correction of iron-deficiency anemia but with frequent gastrointestinal side effects. Milk-derived iron-binding glycoprotein lactoferrin possesses well gastrointestinal tolerance and fewer side effects caused by the intake of high-dose iron....
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MDPI AG
2022-01-01
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| author | Xiya Zhao Xu Zhang Teng Xu Junjie Luo Yongting Luo Peng An |
| author_facet | Xiya Zhao Xu Zhang Teng Xu Junjie Luo Yongting Luo Peng An |
| author_sort | Xiya Zhao |
| collection | DOAJ |
| description | Ferrous sulfate is a commonly used iron supplement for the correction of iron-deficiency anemia but with frequent gastrointestinal side effects. Milk-derived iron-binding glycoprotein lactoferrin possesses well gastrointestinal tolerance and fewer side effects caused by the intake of high-dose iron. However, the underlying mechanism of the iron-enhancing effect of lactoferrin remains unclear. In addition, the comparative efficacies between lactoferrin and ferrous sulfate are also remained to be determined. We conducted a systematic review and meta-analysis on published intervention studies to investigate how lactoferrin modulate iron metabolism and evaluate the comparative effects between lactoferrin and ferrous sulfate supplementation on iron absorption, iron storage, erythropoiesis and inflammation. Lactoferrin supplementation had better effects on serum iron (WMD: 41.44 ug/dL; <i>p</i> < 0.00001), ferritin (WMD: 13.60 ng/mL; <i>p</i> = 0.003) and hemoglobin concentration (11.80 g/dL; <i>p</i> < 0.00001), but a reducing effect on fractional iron absorption (WMD: −2.08%; <i>p</i> = 0.02) and IL-6 levels (WMD: −45.59 pg/mL; <i>p</i> < 0.00001) compared with ferrous sulfate. In conclusion, this study supports lactoferrin as a superior supplement to ferrous sulfate regarding the improvement in serum iron parameters and hemoglobin levels. Considering the weak influence of lactoferrin on iron absorption, the anti-inflammation effect of lactoferrin may be the potential mechanism to explain its efficacy on iron status and erythropoiesis. |
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| last_indexed | 2024-03-09T23:21:36Z |
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| series | Nutrients |
| spelling | doaj.art-9d83e2cd115f435abcf4d8e117f8fda42023-11-23T17:25:29ZengMDPI AGNutrients2072-66432022-01-0114354310.3390/nu14030543Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical TrialsXiya Zhao0Xu Zhang1Teng Xu2Junjie Luo3Yongting Luo4Peng An5Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, ChinaFerrous sulfate is a commonly used iron supplement for the correction of iron-deficiency anemia but with frequent gastrointestinal side effects. Milk-derived iron-binding glycoprotein lactoferrin possesses well gastrointestinal tolerance and fewer side effects caused by the intake of high-dose iron. However, the underlying mechanism of the iron-enhancing effect of lactoferrin remains unclear. In addition, the comparative efficacies between lactoferrin and ferrous sulfate are also remained to be determined. We conducted a systematic review and meta-analysis on published intervention studies to investigate how lactoferrin modulate iron metabolism and evaluate the comparative effects between lactoferrin and ferrous sulfate supplementation on iron absorption, iron storage, erythropoiesis and inflammation. Lactoferrin supplementation had better effects on serum iron (WMD: 41.44 ug/dL; <i>p</i> < 0.00001), ferritin (WMD: 13.60 ng/mL; <i>p</i> = 0.003) and hemoglobin concentration (11.80 g/dL; <i>p</i> < 0.00001), but a reducing effect on fractional iron absorption (WMD: −2.08%; <i>p</i> = 0.02) and IL-6 levels (WMD: −45.59 pg/mL; <i>p</i> < 0.00001) compared with ferrous sulfate. In conclusion, this study supports lactoferrin as a superior supplement to ferrous sulfate regarding the improvement in serum iron parameters and hemoglobin levels. Considering the weak influence of lactoferrin on iron absorption, the anti-inflammation effect of lactoferrin may be the potential mechanism to explain its efficacy on iron status and erythropoiesis.https://www.mdpi.com/2072-6643/14/3/543lactoferrinferrous sulfateiron |
| spellingShingle | Xiya Zhao Xu Zhang Teng Xu Junjie Luo Yongting Luo Peng An Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials Nutrients lactoferrin ferrous sulfate iron |
| title | Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials |
| title_full | Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials |
| title_fullStr | Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials |
| title_full_unstemmed | Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials |
| title_short | Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials |
| title_sort | comparative effects between oral lactoferrin and ferrous sulfate supplementation on iron deficiency anemia a comprehensive review and meta analysis of clinical trials |
| topic | lactoferrin ferrous sulfate iron |
| url | https://www.mdpi.com/2072-6643/14/3/543 |
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