Effect of pamidronate and calcium on implant osseointegration in ovariectomized rats
Introduction: Supplementation with minerals like calcium has been shown to be effective in preventing bone loss and increasing bone density. Thus, it can be assumed that if calcium supplementation is paired with bisphosphonates, greater benefit can be achieved. In this context, we decided to perform...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-09-01
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| Series: | Journal of Craniomaxillofacial Research |
| Subjects: | |
| Online Access: | https://jcr.tums.ac.ir/index.php/jcr/article/view/82 |
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| author | Mehrnoush Momeni Mahboube Hasheminasab Moosa Mahmoodi Mohammad Bayat |
| author_facet | Mehrnoush Momeni Mahboube Hasheminasab Moosa Mahmoodi Mohammad Bayat |
| author_sort | Mehrnoush Momeni |
| collection | DOAJ |
| description | Introduction: Supplementation with minerals like calcium has been shown to be effective in preventing bone loss and increasing bone density. Thus, it can be assumed that if calcium
supplementation is paired with bisphosphonates, greater benefit can be achieved. In this context, we decided to perform this animal study on ovariectomized rats to assess whether bisphosphonate supplemented with calcium can improve implant osseointegration compared to bisphosphonate and calcium alone.
Materials and Methods: In this animal study, 40 ovariectomized rats were divided into 4 groups prior to implant insertion. The first group received 5 mg/kg intramuscular calcium gluconate 3 times per week for 4 weeks. The second group received 5 mg/kg intramuscular pamidronate 3 times per week for 4 weeks. The third group was administrated a combination of both intramuscular calcium gluconate and pamidronate. The control group received no medication. The rats were sacrificed and
the contact surface ratio (CSR) was evaluated 8 weeks after implant insertion in tibial bone.
Result: The pamidronate receiving group had significantly better CSR than the Ca receiving and control groups (P < 0.001). Intravenous calcium did not improve CSR compared to the control group (P = 0.459).
Conclusion: Short-term preoperative intravenous pamidronate can significantly improve bone to implant contact in post-menopausal animal models, whereas calcium supplementation has no beneficial effect.
Keywords: Pamidronate, Calcium, Ovariectomy, Dental Implant |
| first_indexed | 2024-12-19T13:37:24Z |
| format | Article |
| id | doaj.art-9d85c8255e0046409cbb7a0b90be0bfe |
| institution | Directory Open Access Journal |
| issn | 2345-5489 2345-6213 |
| language | English |
| last_indexed | 2024-12-19T13:37:24Z |
| publishDate | 2016-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Craniomaxillofacial Research |
| spelling | doaj.art-9d85c8255e0046409cbb7a0b90be0bfe2022-12-21T20:19:09ZengTehran University of Medical SciencesJournal of Craniomaxillofacial Research2345-54892345-62132016-09-0111-2Effect of pamidronate and calcium on implant osseointegration in ovariectomized ratsMehrnoush Momeni0Mahboube Hasheminasab1Moosa Mahmoodi2Mohammad Bayat3Craniomaxillofacial Research Center, Shariati Hospita AND Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranCraniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranCraniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranCraniomaxillofacial Research Center, Shariati Hospita AND Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranIntroduction: Supplementation with minerals like calcium has been shown to be effective in preventing bone loss and increasing bone density. Thus, it can be assumed that if calcium supplementation is paired with bisphosphonates, greater benefit can be achieved. In this context, we decided to perform this animal study on ovariectomized rats to assess whether bisphosphonate supplemented with calcium can improve implant osseointegration compared to bisphosphonate and calcium alone. Materials and Methods: In this animal study, 40 ovariectomized rats were divided into 4 groups prior to implant insertion. The first group received 5 mg/kg intramuscular calcium gluconate 3 times per week for 4 weeks. The second group received 5 mg/kg intramuscular pamidronate 3 times per week for 4 weeks. The third group was administrated a combination of both intramuscular calcium gluconate and pamidronate. The control group received no medication. The rats were sacrificed and the contact surface ratio (CSR) was evaluated 8 weeks after implant insertion in tibial bone. Result: The pamidronate receiving group had significantly better CSR than the Ca receiving and control groups (P < 0.001). Intravenous calcium did not improve CSR compared to the control group (P = 0.459). Conclusion: Short-term preoperative intravenous pamidronate can significantly improve bone to implant contact in post-menopausal animal models, whereas calcium supplementation has no beneficial effect. Keywords: Pamidronate, Calcium, Ovariectomy, Dental Implanthttps://jcr.tums.ac.ir/index.php/jcr/article/view/82PamidronateCalciumOvariectomyDental Implant |
| spellingShingle | Mehrnoush Momeni Mahboube Hasheminasab Moosa Mahmoodi Mohammad Bayat Effect of pamidronate and calcium on implant osseointegration in ovariectomized rats Journal of Craniomaxillofacial Research Pamidronate Calcium Ovariectomy Dental Implant |
| title | Effect of pamidronate and calcium on implant osseointegration in ovariectomized rats |
| title_full | Effect of pamidronate and calcium on implant osseointegration in ovariectomized rats |
| title_fullStr | Effect of pamidronate and calcium on implant osseointegration in ovariectomized rats |
| title_full_unstemmed | Effect of pamidronate and calcium on implant osseointegration in ovariectomized rats |
| title_short | Effect of pamidronate and calcium on implant osseointegration in ovariectomized rats |
| title_sort | effect of pamidronate and calcium on implant osseointegration in ovariectomized rats |
| topic | Pamidronate Calcium Ovariectomy Dental Implant |
| url | https://jcr.tums.ac.ir/index.php/jcr/article/view/82 |
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