HIV and malaria co-infection in Mumbai, western Indi
Background & objectives: Conflicting reports exist regarding the HIV-1 infection on the risk of malaria. Atransient almost one-log elevation in HIV viral load occurs during febrile malaria episodes. We prospectivelystudied malaria patients for HIV infection from Mumbai.Methods: A total of 171 ma...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-09-01
|
| Series: | Journal of Vector Borne Diseases |
| Subjects: | |
| Online Access: | http://www.mrcindia.org/journal/issues/483155.pdf |
| _version_ | 1818257338992164864 |
|---|---|
| author | U. Shankarkumar, A. Shankarkumar & K. Ghosh |
| author_facet | U. Shankarkumar, A. Shankarkumar & K. Ghosh |
| author_sort | U. Shankarkumar, A. Shankarkumar & K. Ghosh |
| collection | DOAJ |
| description | Background & objectives: Conflicting reports exist regarding the HIV-1 infection on the risk of malaria. Atransient almost one-log elevation in HIV viral load occurs during febrile malaria episodes. We prospectivelystudied malaria patients for HIV infection from Mumbai.Methods: A total of 171 malaria patients and 28,749 normal voluntary blood donors were studied for their HIVstatus. Diagnosis of malaria was done by microscopical examination of blood. HIV screening was done bydetection of HIV-1 & 2 antibodies by micro well ELISA using Enzaids & J Mitra kits followed by confirmationusing western blot (Innogenetics, Belgium) analysis.Results: Out of 171 malaria patients 13 (7.6%; Odds ratio= 4.45; p <0.0001) and 521 blood bank donors werefound to be HIV reactive. Among 13 HIV reactive patients, eight patients were Elisa borderline reactive andwestern blot positive (p24), which may be due to cross-reactive antibodies. Five of 13 malaria patients foundto be HIV-1 positive by ELISA and by western blot confirming HIV and malaria co-infection.Conclusion: Our findings suggest that HIV-1 and malaria co-infection can’t be ruled out in malaria endemiccountries like India |
| first_indexed | 2024-12-12T17:42:04Z |
| format | Article |
| id | doaj.art-9d863293baa94f7c8cb723aa1798c611 |
| institution | Directory Open Access Journal |
| issn | 0972-9062 |
| language | English |
| last_indexed | 2024-12-12T17:42:04Z |
| publishDate | 2011-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Vector Borne Diseases |
| spelling | doaj.art-9d863293baa94f7c8cb723aa1798c6112022-12-22T00:17:02ZengWolters Kluwer Medknow PublicationsJournal of Vector Borne Diseases0972-90622011-09-01483155158HIV and malaria co-infection in Mumbai, western IndiU. Shankarkumar, A. Shankarkumar & K. GhoshBackground & objectives: Conflicting reports exist regarding the HIV-1 infection on the risk of malaria. Atransient almost one-log elevation in HIV viral load occurs during febrile malaria episodes. We prospectivelystudied malaria patients for HIV infection from Mumbai.Methods: A total of 171 malaria patients and 28,749 normal voluntary blood donors were studied for their HIVstatus. Diagnosis of malaria was done by microscopical examination of blood. HIV screening was done bydetection of HIV-1 & 2 antibodies by micro well ELISA using Enzaids & J Mitra kits followed by confirmationusing western blot (Innogenetics, Belgium) analysis.Results: Out of 171 malaria patients 13 (7.6%; Odds ratio= 4.45; p <0.0001) and 521 blood bank donors werefound to be HIV reactive. Among 13 HIV reactive patients, eight patients were Elisa borderline reactive andwestern blot positive (p24), which may be due to cross-reactive antibodies. Five of 13 malaria patients foundto be HIV-1 positive by ELISA and by western blot confirming HIV and malaria co-infection.Conclusion: Our findings suggest that HIV-1 and malaria co-infection can’t be ruled out in malaria endemiccountries like Indiahttp://www.mrcindia.org/journal/issues/483155.pdfHIV-1 co-infectionmalariaMumbaiwestern India |
| spellingShingle | U. Shankarkumar, A. Shankarkumar & K. Ghosh HIV and malaria co-infection in Mumbai, western Indi Journal of Vector Borne Diseases HIV-1 co-infection malaria Mumbai western India |
| title | HIV and malaria co-infection in Mumbai, western Indi |
| title_full | HIV and malaria co-infection in Mumbai, western Indi |
| title_fullStr | HIV and malaria co-infection in Mumbai, western Indi |
| title_full_unstemmed | HIV and malaria co-infection in Mumbai, western Indi |
| title_short | HIV and malaria co-infection in Mumbai, western Indi |
| title_sort | hiv and malaria co infection in mumbai western indi |
| topic | HIV-1 co-infection malaria Mumbai western India |
| url | http://www.mrcindia.org/journal/issues/483155.pdf |
| work_keys_str_mv | AT ushankarkumarashankarkumarkghosh hivandmalariacoinfectioninmumbaiwesternindi |