Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life.
Objectives: Deficit in visuospatial functions can influence both simple and complex daily life activities. Despite the fact that visuospatial deficit was reported in schizophrenia, research on visuospatial functions as an independent entity is limited. Our study aims to elucidate the impact of visu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00322/full |
| _version_ | 1818139337999515648 |
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| author | Mabel eRodriguez Filip eSpaniel Filip eSpaniel Lucie eKonradova Katerina eSedlakova Katerina eSedlakova Karolina eDvorska Jitka ePrajsova Zuzana eKratochvilova David eLevcik Kamil eVlcek Kamil eVlcek Iveta eFajnerova Iveta eFajnerova Iveta eFajnerova |
| author_facet | Mabel eRodriguez Filip eSpaniel Filip eSpaniel Lucie eKonradova Katerina eSedlakova Katerina eSedlakova Karolina eDvorska Jitka ePrajsova Zuzana eKratochvilova David eLevcik Kamil eVlcek Kamil eVlcek Iveta eFajnerova Iveta eFajnerova Iveta eFajnerova |
| author_sort | Mabel eRodriguez |
| collection | DOAJ |
| description | Objectives: Deficit in visuospatial functions can influence both simple and complex daily life activities. Despite the fact that visuospatial deficit was reported in schizophrenia, research on visuospatial functions as an independent entity is limited. Our study aims to elucidate the impact of visuospatial deficit in comparison with verbal deficit on global functioning and quality of life in the first psychotic episode of schizophrenia spectrum disorder (FES). The significance of clinical symptoms and antipsychotic medication was also studied. Methods: Thirty-six FES patients and a matched group of healthy controls (HC group) were assessed with a neuropsychological battery focused on visuospatial (VIS) and verbal (VERB) functions. Using multiple regression analysis, we evaluated the cumulative effect of VERB and VIS functions, psychiatric symptoms (PANSS) and antipsychotic medication on global functioning (GAF) and quality of life (WHOQOL-BREF) in the FES group.Results: The FES group demonstrated significant impairment both in VIS and VERB cognitive abilities compared to the HC group. Antipsychotic medication did not significantly affect either VIS or VERB functioning. PANSS was not related to cognitive functioning, apart from the Trail Making Test B. In the FES group, the GAF score was significantly affected by the severity of positive symptoms and VERB functioning, explaining together 60% of GAF variability. The severity of negative and positive symptoms affected only the Physical health domain of WHOQOL-BREF. The degree of VERB deficit was associated with both Physical and Psychological health. Although we did not find any relation between VIS functioning, GAF, and WHOQOL-BREF, a paradoxical finding emerged in the Environment quality domain, where a worse quality of the environment was associated with better VIS functioning. Conclusions: Our results suggest that the deficit in VIS functions is an integral part of cognitive deficit in schizophrenia spectrum disorders, rather than a side effect of symptomatology or antipsychotic medication. Moreover, VERB functioning was a better predictor of GAF and WHOQOL-BREF than VIS functioning. Given the findings of negative or missing effect of VIS deficit on WHOQOL-BREF and GAF, the accuracy of these measures in evaluating the impact of global cognitive deficit on everyday life in schizophrenia could be questioned. |
| first_indexed | 2024-12-11T10:26:30Z |
| format | Article |
| id | doaj.art-9d8697832eba440bacc24923624ff4f9 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-11T10:26:30Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-9d8697832eba440bacc24923624ff4f92022-12-22T01:11:09ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532015-12-01910.3389/fnbeh.2015.00322165231Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life.Mabel eRodriguez0Filip eSpaniel1Filip eSpaniel2Lucie eKonradova3Katerina eSedlakova4Katerina eSedlakova5Karolina eDvorska6Jitka ePrajsova7Zuzana eKratochvilova8David eLevcik9Kamil eVlcek10Kamil eVlcek11Iveta eFajnerova12Iveta eFajnerova13Iveta eFajnerova14National Institute of Mental HealthNational Institute of Mental HealthThird Faculty of Medicine, Charles University in PragueNational Institute of Mental HealthNational Institute of Mental HealthThird Faculty of Medicine, Charles University in PragueThird Faculty of Medicine, Charles University in PragueNational Institute of Mental HealthNational Institute of Mental HealthInstitute of Physiology CASNational Institute of Mental HealthInstitute of Physiology CASNational Institute of Mental HealthInstitute of Physiology CASThird Faculty of Medicine, Charles University in PragueObjectives: Deficit in visuospatial functions can influence both simple and complex daily life activities. Despite the fact that visuospatial deficit was reported in schizophrenia, research on visuospatial functions as an independent entity is limited. Our study aims to elucidate the impact of visuospatial deficit in comparison with verbal deficit on global functioning and quality of life in the first psychotic episode of schizophrenia spectrum disorder (FES). The significance of clinical symptoms and antipsychotic medication was also studied. Methods: Thirty-six FES patients and a matched group of healthy controls (HC group) were assessed with a neuropsychological battery focused on visuospatial (VIS) and verbal (VERB) functions. Using multiple regression analysis, we evaluated the cumulative effect of VERB and VIS functions, psychiatric symptoms (PANSS) and antipsychotic medication on global functioning (GAF) and quality of life (WHOQOL-BREF) in the FES group.Results: The FES group demonstrated significant impairment both in VIS and VERB cognitive abilities compared to the HC group. Antipsychotic medication did not significantly affect either VIS or VERB functioning. PANSS was not related to cognitive functioning, apart from the Trail Making Test B. In the FES group, the GAF score was significantly affected by the severity of positive symptoms and VERB functioning, explaining together 60% of GAF variability. The severity of negative and positive symptoms affected only the Physical health domain of WHOQOL-BREF. The degree of VERB deficit was associated with both Physical and Psychological health. Although we did not find any relation between VIS functioning, GAF, and WHOQOL-BREF, a paradoxical finding emerged in the Environment quality domain, where a worse quality of the environment was associated with better VIS functioning. Conclusions: Our results suggest that the deficit in VIS functions is an integral part of cognitive deficit in schizophrenia spectrum disorders, rather than a side effect of symptomatology or antipsychotic medication. Moreover, VERB functioning was a better predictor of GAF and WHOQOL-BREF than VIS functioning. Given the findings of negative or missing effect of VIS deficit on WHOQOL-BREF and GAF, the accuracy of these measures in evaluating the impact of global cognitive deficit on everyday life in schizophrenia could be questioned.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00322/fullQuality of Lifeantipsychotic medicationcognitive deficitGlobal functioningverbal functionsclinical symptoms |
| spellingShingle | Mabel eRodriguez Filip eSpaniel Filip eSpaniel Lucie eKonradova Katerina eSedlakova Katerina eSedlakova Karolina eDvorska Jitka ePrajsova Zuzana eKratochvilova David eLevcik Kamil eVlcek Kamil eVlcek Iveta eFajnerova Iveta eFajnerova Iveta eFajnerova Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life. Frontiers in Behavioral Neuroscience Quality of Life antipsychotic medication cognitive deficit Global functioning verbal functions clinical symptoms |
| title | Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life. |
| title_full | Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life. |
| title_fullStr | Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life. |
| title_full_unstemmed | Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life. |
| title_short | Comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder: impact on global functioning and quality of life. |
| title_sort | comparison of visuospatial and verbal abilities in first psychotic episode of schizophrenia spectrum disorder impact on global functioning and quality of life |
| topic | Quality of Life antipsychotic medication cognitive deficit Global functioning verbal functions clinical symptoms |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00322/full |
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