A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease.

A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease.

BACKGROUND:Patients with chronic kidney disease (CKD) have increased risk of development of end-stage renal disease (ESRD) and early mortality. Fibrosis is the central pathogenic process in CKD and is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 chain (LAMC1) is a cor...

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Bibliographic Details
Main Authors: Signe Holm Nielsen, Daniel Guldager Kring Rasmussen, Susanne Brix, Anthony Fenton, Mark Jesky, Charles J Ferro, Morten Karsdal, Federica Genovese, Paul Cockwell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6166934?pdf=render

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