Decreased Muscle Strength and Quality in Diabetes-Related Dementia
Background/Aims: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, q...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2017-12-01
|
| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/485177 |
| _version_ | 1818203062011953152 |
|---|---|
| author | Akito Tsugawa Yusuke Ogawa Naoto Takenoshita Yoshitsugu Kaneko Hirokuni Hatanaka Eriko Jaime Raita Fukasawa Haruo Hanyu |
| author_facet | Akito Tsugawa Yusuke Ogawa Naoto Takenoshita Yoshitsugu Kaneko Hirokuni Hatanaka Eriko Jaime Raita Fukasawa Haruo Hanyu |
| author_sort | Akito Tsugawa |
| collection | DOAJ |
| description | Background/Aims: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, quality, and mass decrease in individuals with DrD. Methods: We evaluated grip and knee extension strength, muscle mass, and gait speed in 106 patients with probable AD and without type 2 DM (AD[–DM] group), 74 patients with probable AD and with DM (AD[+DM] group), and 36 patients with DrD (DrD group). Muscle quality was defined as the ratio of muscle strength to muscle mass. Results: Both female and male subjects with DrD showed significantly decreased muscle strength and quality in the upper extremities compared with the subjects with AD[–DM] or AD[+DM]. Female subjects with DrD showed significantly decreased muscle quality in the lower extremities compared with the subjects with AD[–DM]. Both female and male subjects with DrD had a significantly lower gait speed compared with the subjects with AD[–DM]. However, there were no significant differences in muscle mass and the prevalence of sarcopenia between the groups. Conclusion: Subjects with DrD showed decreased muscle strength and quality, but not muscle mass, and had a low gait speed. |
| first_indexed | 2024-12-12T03:19:22Z |
| format | Article |
| id | doaj.art-9d88d939f6694046bc635d1757ef0d5d |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-12T03:19:22Z |
| publishDate | 2017-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-9d88d939f6694046bc635d1757ef0d5d2022-12-22T00:40:13ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642017-12-017345446210.1159/000485177485177Decreased Muscle Strength and Quality in Diabetes-Related DementiaAkito TsugawaYusuke OgawaNaoto TakenoshitaYoshitsugu KanekoHirokuni HatanakaEriko JaimeRaita FukasawaHaruo HanyuBackground/Aims: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, quality, and mass decrease in individuals with DrD. Methods: We evaluated grip and knee extension strength, muscle mass, and gait speed in 106 patients with probable AD and without type 2 DM (AD[–DM] group), 74 patients with probable AD and with DM (AD[+DM] group), and 36 patients with DrD (DrD group). Muscle quality was defined as the ratio of muscle strength to muscle mass. Results: Both female and male subjects with DrD showed significantly decreased muscle strength and quality in the upper extremities compared with the subjects with AD[–DM] or AD[+DM]. Female subjects with DrD showed significantly decreased muscle quality in the lower extremities compared with the subjects with AD[–DM]. Both female and male subjects with DrD had a significantly lower gait speed compared with the subjects with AD[–DM]. However, there were no significant differences in muscle mass and the prevalence of sarcopenia between the groups. Conclusion: Subjects with DrD showed decreased muscle strength and quality, but not muscle mass, and had a low gait speed.https://www.karger.com/Article/FullText/485177DementiaAlzheimer diseaseDiabetes mellitusMuscleSarcopeniaDynapenia |
| spellingShingle | Akito Tsugawa Yusuke Ogawa Naoto Takenoshita Yoshitsugu Kaneko Hirokuni Hatanaka Eriko Jaime Raita Fukasawa Haruo Hanyu Decreased Muscle Strength and Quality in Diabetes-Related Dementia Dementia and Geriatric Cognitive Disorders Extra Dementia Alzheimer disease Diabetes mellitus Muscle Sarcopenia Dynapenia |
| title | Decreased Muscle Strength and Quality in Diabetes-Related Dementia |
| title_full | Decreased Muscle Strength and Quality in Diabetes-Related Dementia |
| title_fullStr | Decreased Muscle Strength and Quality in Diabetes-Related Dementia |
| title_full_unstemmed | Decreased Muscle Strength and Quality in Diabetes-Related Dementia |
| title_short | Decreased Muscle Strength and Quality in Diabetes-Related Dementia |
| title_sort | decreased muscle strength and quality in diabetes related dementia |
| topic | Dementia Alzheimer disease Diabetes mellitus Muscle Sarcopenia Dynapenia |
| url | https://www.karger.com/Article/FullText/485177 |
| work_keys_str_mv | AT akitotsugawa decreasedmusclestrengthandqualityindiabetesrelateddementia AT yusukeogawa decreasedmusclestrengthandqualityindiabetesrelateddementia AT naototakenoshita decreasedmusclestrengthandqualityindiabetesrelateddementia AT yoshitsugukaneko decreasedmusclestrengthandqualityindiabetesrelateddementia AT hirokunihatanaka decreasedmusclestrengthandqualityindiabetesrelateddementia AT erikojaime decreasedmusclestrengthandqualityindiabetesrelateddementia AT raitafukasawa decreasedmusclestrengthandqualityindiabetesrelateddementia AT haruohanyu decreasedmusclestrengthandqualityindiabetesrelateddementia |