Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells

Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells

Abstract Fibroblast growth factors (FGFs) control various cellular functions through fibroblast growth factor receptor (FGFR) activation, including proliferation, differentiation, migration, and survival. FGFR amplification in ER + breast cancer patients correlate with poor prognosis, and FGFR inhib...

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Bibliographic Details
Main Authors: Feng Chi, Jason I. Griffiths, Aritro Nath, Andrea H. Bild
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Breast Cancer Research
Subjects:
FGF2
FGFR1
p21
JAK-STAT
Stemness
Online Access:https://doi.org/10.1186/s13058-024-01808-7

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