Self-organization and shape change by active polarization in nematic droplets
Active forces drive critical biological processes such as spontaneous organization and shape change during cell division. Here, we present a minimal hydrodynamic model leading to a unified description of self-organization and division in nematic droplets through active polarity sorting of cytoskelet...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2021-10-01
|
| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.3.043061 |
| _version_ | 1797210944348094464 |
|---|---|
| author | Fabian Jan Schwarzendahl Pierre Ronceray Kimberly L. Weirich Kinjal Dasbiswas |
| author_facet | Fabian Jan Schwarzendahl Pierre Ronceray Kimberly L. Weirich Kinjal Dasbiswas |
| author_sort | Fabian Jan Schwarzendahl |
| collection | DOAJ |
| description | Active forces drive critical biological processes such as spontaneous organization and shape change during cell division. Here, we present a minimal hydrodynamic model leading to a unified description of self-organization and division in nematic droplets through active polarity sorting of cytoskeletal filaments by molecular motors. We find that motors self-organize within droplets while structuring filaments into polarized aster defects. At large activity, motors deform droplets leading to multidroplet chains and droplet division, consistent with experiments on actomyosin tactoids. We predict droplet steady-state phase diagrams that inform programmable shape changes in confined soft materials. |
| first_indexed | 2024-04-24T10:18:38Z |
| format | Article |
| id | doaj.art-9d8d5b08852942b784b2abe2afabedf2 |
| institution | Directory Open Access Journal |
| issn | 2643-1564 |
| language | English |
| last_indexed | 2024-04-24T10:18:38Z |
| publishDate | 2021-10-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj.art-9d8d5b08852942b784b2abe2afabedf22024-04-12T17:15:02ZengAmerican Physical SocietyPhysical Review Research2643-15642021-10-013404306110.1103/PhysRevResearch.3.043061Self-organization and shape change by active polarization in nematic dropletsFabian Jan SchwarzendahlPierre RoncerayKimberly L. WeirichKinjal DasbiswasActive forces drive critical biological processes such as spontaneous organization and shape change during cell division. Here, we present a minimal hydrodynamic model leading to a unified description of self-organization and division in nematic droplets through active polarity sorting of cytoskeletal filaments by molecular motors. We find that motors self-organize within droplets while structuring filaments into polarized aster defects. At large activity, motors deform droplets leading to multidroplet chains and droplet division, consistent with experiments on actomyosin tactoids. We predict droplet steady-state phase diagrams that inform programmable shape changes in confined soft materials.http://doi.org/10.1103/PhysRevResearch.3.043061 |
| spellingShingle | Fabian Jan Schwarzendahl Pierre Ronceray Kimberly L. Weirich Kinjal Dasbiswas Self-organization and shape change by active polarization in nematic droplets Physical Review Research |
| title | Self-organization and shape change by active polarization in nematic droplets |
| title_full | Self-organization and shape change by active polarization in nematic droplets |
| title_fullStr | Self-organization and shape change by active polarization in nematic droplets |
| title_full_unstemmed | Self-organization and shape change by active polarization in nematic droplets |
| title_short | Self-organization and shape change by active polarization in nematic droplets |
| title_sort | self organization and shape change by active polarization in nematic droplets |
| url | http://doi.org/10.1103/PhysRevResearch.3.043061 |
| work_keys_str_mv | AT fabianjanschwarzendahl selforganizationandshapechangebyactivepolarizationinnematicdroplets AT pierreronceray selforganizationandshapechangebyactivepolarizationinnematicdroplets AT kimberlylweirich selforganizationandshapechangebyactivepolarizationinnematicdroplets AT kinjaldasbiswas selforganizationandshapechangebyactivepolarizationinnematicdroplets |