Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysis
Aim. Analysis of the efficacy and safety of the new oral anticoagulants (NOACs) in the management of venous thromboembolism (VTE).Material and methods. This meta-analysis of randomized controlled trials (RCTs) was made in accordance with the instructions “Preferred reporting items for systematic rev...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2017-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.com/jour/article/view/1192 |
| _version_ | 1797659265011286016 |
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| author | V. I. Petrov O. V. Shatalova V. S. Gorbatenko O. N. Smuseva A. S. Maslakov |
| author_facet | V. I. Petrov O. V. Shatalova V. S. Gorbatenko O. N. Smuseva A. S. Maslakov |
| author_sort | V. I. Petrov |
| collection | DOAJ |
| description | Aim. Analysis of the efficacy and safety of the new oral anticoagulants (NOACs) in the management of venous thromboembolism (VTE).Material and methods. This meta-analysis of randomized controlled trials (RCTs) was made in accordance with the instructions “Preferred reporting items for systematic reviews and meta-analyses (PRISMA)”.Results. The meta-analysis included 5 RCTs. NOACs were as effective as vitamin K antagonists (VKAs) in preventing recurrent symptomatic VTE (RR=0.93; 95% CI 0.77-1.12; p=0.44). The incidence of recurrent thrombosis (RR=0.82; 95% CI 0.63-1.08; p=0.16) and deep vein thrombosis ± fatal or nonfatal pulmonary embolism (RR=1.06; 95% CI 0.81-1.40; p=0.66) was comparable in the groups of comparison. Meta-analysis of the safety of the NOACs suggested significant reduction of risk of major bleeding as compared with standard therapy (RR=0.54; 95% CI 0.42-0.69; р<0.00001). The incidence of all types of bleeding was significantly lower with NOACs (RR=0.70; 95% CI 0.51-0.95; p=0.02). All-cause mortality rate was comparable between the groups (RR=0.93; 95% CI 0.76-1.13; p=0.46).Conclusions. NOACs are as effective as the standard therapy, at that they are much safer in VTE treatment. |
| first_indexed | 2024-03-11T18:12:19Z |
| format | Article |
| id | doaj.art-9d8dedf094e04bd2bad02299793f88c3 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-11T18:12:19Z |
| publishDate | 2017-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-9d8dedf094e04bd2bad02299793f88c32023-10-16T11:32:19ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532017-01-0112631391895Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysisV. I. Petrov0O. V. Shatalova1V. S. Gorbatenko2O. N. Smuseva3A. S. Maslakov4Volgograd State Medical University. Pavshikh Bortsov pl. 1, Volgograd, 400131 RussiaVolgograd State Medical University. Pavshikh Bortsov pl. 1, Volgograd, 400131 RussiaVolgograd State Medical University. Pavshikh Bortsov pl. 1, Volgograd, 400131 RussiaVolgograd State Medical University. Pavshikh Bortsov pl. 1, Volgograd, 400131 RussiaVolgograd State Medical University. Pavshikh Bortsov pl. 1, Volgograd, 400131 RussiaAim. Analysis of the efficacy and safety of the new oral anticoagulants (NOACs) in the management of venous thromboembolism (VTE).Material and methods. This meta-analysis of randomized controlled trials (RCTs) was made in accordance with the instructions “Preferred reporting items for systematic reviews and meta-analyses (PRISMA)”.Results. The meta-analysis included 5 RCTs. NOACs were as effective as vitamin K antagonists (VKAs) in preventing recurrent symptomatic VTE (RR=0.93; 95% CI 0.77-1.12; p=0.44). The incidence of recurrent thrombosis (RR=0.82; 95% CI 0.63-1.08; p=0.16) and deep vein thrombosis ± fatal or nonfatal pulmonary embolism (RR=1.06; 95% CI 0.81-1.40; p=0.66) was comparable in the groups of comparison. Meta-analysis of the safety of the NOACs suggested significant reduction of risk of major bleeding as compared with standard therapy (RR=0.54; 95% CI 0.42-0.69; р<0.00001). The incidence of all types of bleeding was significantly lower with NOACs (RR=0.70; 95% CI 0.51-0.95; p=0.02). All-cause mortality rate was comparable between the groups (RR=0.93; 95% CI 0.76-1.13; p=0.46).Conclusions. NOACs are as effective as the standard therapy, at that they are much safer in VTE treatment.https://www.rpcardio.com/jour/article/view/1192randomized clinical trialsmeta-analysisnew oral anticoagulantsvenous thromboembolism |
| spellingShingle | V. I. Petrov O. V. Shatalova V. S. Gorbatenko O. N. Smuseva A. S. Maslakov Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysis Рациональная фармакотерапия в кардиологии randomized clinical trials meta-analysis new oral anticoagulants venous thromboembolism |
| title | Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysis |
| title_full | Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysis |
| title_fullStr | Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysis |
| title_full_unstemmed | Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysis |
| title_short | Efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications: meta-analysis |
| title_sort | efficacy and safety of the new oral anticoagulants in the treatment of venous thromboembolic complications meta analysis |
| topic | randomized clinical trials meta-analysis new oral anticoagulants venous thromboembolism |
| url | https://www.rpcardio.com/jour/article/view/1192 |
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