<i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice
Stroke is a major global health problem that causes significant mortality and long-term disability. Post-stroke neurological impairment is a complication that is often underestimated with the risk of persistent neurological deficits. Although traditional Chinese medicines have a long history of bein...
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MDPI AG
2023-08-01
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| author | Ho-won Seo Tae-Young Ha Geon Ko Aram Jang Ji-Woong Choi Dong-hun Lee Keun-A Chang |
| author_facet | Ho-won Seo Tae-Young Ha Geon Ko Aram Jang Ji-Woong Choi Dong-hun Lee Keun-A Chang |
| author_sort | Ho-won Seo |
| collection | DOAJ |
| description | Stroke is a major global health problem that causes significant mortality and long-term disability. Post-stroke neurological impairment is a complication that is often underestimated with the risk of persistent neurological deficits. Although traditional Chinese medicines have a long history of being used for stroke, their scientific efficacy remains unclear. <i>Scutellaria baicalensis</i>, an herbal component known for its anti-inflammatory and antioxidant properties, has traditionally been used to treat brain disorders. This study investigated the therapeutic effects of the <i>Scutellaria baicalensis</i> extraction (SB) during the acute stage of ischemic stroke using photothrombotic (PTB)-induced and transient middle cerebral artery occlusion (tMCAO) model mice. We found that SB mitigated ischemic brain injury, as evidenced by a significant reduction in the modified neurological severity score in the acute stage of PTB and both the acute and chronic stages of tMCAO. Furthermore, we elucidated the regulatory role of SB in the necroptosis and pyroptosis pathways during the acute stage of stroke, underscoring its protective effects. Behavioral assessments demonstrated the effectiveness of SB in ameliorating motor dysfunction and cognitive impairment compared to the group receiving the vehicle. Our findings highlight the potential of SB as a promising therapeutic candidate for stroke. SB was found to help modulate the programmed cell death pathways, promote neuroprotection, and facilitate functional recovery. |
| first_indexed | 2024-03-10T23:25:57Z |
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| language | English |
| last_indexed | 2024-03-10T23:25:57Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-9d90fb5ce14f452da6769e47f926f5982023-11-19T07:57:42ZengMDPI AGCells2073-44092023-08-011217213310.3390/cells12172133<i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke MiceHo-won Seo0Tae-Young Ha1Geon Ko2Aram Jang3Ji-Woong Choi4Dong-hun Lee5Keun-A Chang6Department of Health Science and Technology, Gachon Advanced Institute for Health Sciences & Technology, Gachon University, Incheon 21999, Republic of KoreaNeuroscience Research Institute, Gachon University, Incheon 21565, Republic of KoreaDepartment of Health Science and Technology, Gachon Advanced Institute for Health Sciences & Technology, Gachon University, Incheon 21999, Republic of KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of KoreaCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Republic of KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of KoreaDepartment of Health Science and Technology, Gachon Advanced Institute for Health Sciences & Technology, Gachon University, Incheon 21999, Republic of KoreaStroke is a major global health problem that causes significant mortality and long-term disability. Post-stroke neurological impairment is a complication that is often underestimated with the risk of persistent neurological deficits. Although traditional Chinese medicines have a long history of being used for stroke, their scientific efficacy remains unclear. <i>Scutellaria baicalensis</i>, an herbal component known for its anti-inflammatory and antioxidant properties, has traditionally been used to treat brain disorders. This study investigated the therapeutic effects of the <i>Scutellaria baicalensis</i> extraction (SB) during the acute stage of ischemic stroke using photothrombotic (PTB)-induced and transient middle cerebral artery occlusion (tMCAO) model mice. We found that SB mitigated ischemic brain injury, as evidenced by a significant reduction in the modified neurological severity score in the acute stage of PTB and both the acute and chronic stages of tMCAO. Furthermore, we elucidated the regulatory role of SB in the necroptosis and pyroptosis pathways during the acute stage of stroke, underscoring its protective effects. Behavioral assessments demonstrated the effectiveness of SB in ameliorating motor dysfunction and cognitive impairment compared to the group receiving the vehicle. Our findings highlight the potential of SB as a promising therapeutic candidate for stroke. SB was found to help modulate the programmed cell death pathways, promote neuroprotection, and facilitate functional recovery.https://www.mdpi.com/2073-4409/12/17/2133stroke<i>Scutellaria baicalensis</i>transient MCAOphotothrombotic stroke modelnecroptosispyroptosis |
| spellingShingle | Ho-won Seo Tae-Young Ha Geon Ko Aram Jang Ji-Woong Choi Dong-hun Lee Keun-A Chang <i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice Cells stroke <i>Scutellaria baicalensis</i> transient MCAO photothrombotic stroke model necroptosis pyroptosis |
| title | <i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice |
| title_full | <i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice |
| title_fullStr | <i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice |
| title_full_unstemmed | <i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice |
| title_short | <i>Scutellaria baicalensis</i> Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice |
| title_sort | i scutellaria baicalensis i attenuated neurological impairment by regulating programmed cell death pathway in ischemic stroke mice |
| topic | stroke <i>Scutellaria baicalensis</i> transient MCAO photothrombotic stroke model necroptosis pyroptosis |
| url | https://www.mdpi.com/2073-4409/12/17/2133 |
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