Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states
Summary: The relationship between sensory stimuli and perceptions is brain-state dependent: in wakefulness, suprathreshold stimuli evoke perceptions; under anesthesia, perceptions are abolished; and during dreaming and in dissociated states, percepts are internally generated. Here, we exploit this s...
| 主要な著者: | , , , , , |
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
Elsevier
2024-04-01
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| シリーズ: | Cell Reports |
| 主題: | |
| オンライン･アクセス: | http://www.sciencedirect.com/science/article/pii/S2211124724003450 |
| _version_ | 1827292733309452288 |
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| author | Adeeti Aggarwal Jennifer Luo Helen Chung Diego Contreras Max B. Kelz Alex Proekt |
| author_facet | Adeeti Aggarwal Jennifer Luo Helen Chung Diego Contreras Max B. Kelz Alex Proekt |
| author_sort | Adeeti Aggarwal |
| collection | DOAJ |
| description | Summary: The relationship between sensory stimuli and perceptions is brain-state dependent: in wakefulness, suprathreshold stimuli evoke perceptions; under anesthesia, perceptions are abolished; and during dreaming and in dissociated states, percepts are internally generated. Here, we exploit this state dependence to identify brain activity associated with internally generated or stimulus-evoked perceptions. In awake mice, visual stimuli phase reset spontaneous cortical waves to elicit 3–6 Hz feedback traveling waves. These stimulus-evoked waves traverse the cortex and entrain visual and parietal neurons. Under anesthesia as well as during ketamine-induced dissociation, visual stimuli do not disrupt spontaneous waves. Uniquely, in the dissociated state, spontaneous waves traverse the cortex caudally and entrain visual and parietal neurons, akin to stimulus-evoked waves in wakefulness. Thus, coordinated neuronal assemblies orchestrated by traveling cortical waves emerge in states in which perception can manifest. The awake state is privileged in that this coordination is reliably elicited by external visual stimuli. |
| first_indexed | 2024-04-24T13:10:52Z |
| format | Article |
| id | doaj.art-9d9126ac6f5545f9a575657270097728 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-24T13:10:52Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-9d9126ac6f5545f9a5756572700977282024-04-05T04:40:30ZengElsevierCell Reports2211-12472024-04-01434114017Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain statesAdeeti Aggarwal0Jennifer Luo1Helen Chung2Diego Contreras3Max B. Kelz4Alex Proekt5Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USASchool of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USAThe College of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA; Mahoney Institute for Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Mahoney Institute for Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for the Neuroscience of Unconsciousness and Reanimation Research Alliance (NEURRAL), University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Mahoney Institute for Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for the Neuroscience of Unconsciousness and Reanimation Research Alliance (NEURRAL), University of Pennsylvania, Philadelphia, PA 19104, USA; Corresponding authorSummary: The relationship between sensory stimuli and perceptions is brain-state dependent: in wakefulness, suprathreshold stimuli evoke perceptions; under anesthesia, perceptions are abolished; and during dreaming and in dissociated states, percepts are internally generated. Here, we exploit this state dependence to identify brain activity associated with internally generated or stimulus-evoked perceptions. In awake mice, visual stimuli phase reset spontaneous cortical waves to elicit 3–6 Hz feedback traveling waves. These stimulus-evoked waves traverse the cortex and entrain visual and parietal neurons. Under anesthesia as well as during ketamine-induced dissociation, visual stimuli do not disrupt spontaneous waves. Uniquely, in the dissociated state, spontaneous waves traverse the cortex caudally and entrain visual and parietal neurons, akin to stimulus-evoked waves in wakefulness. Thus, coordinated neuronal assemblies orchestrated by traveling cortical waves emerge in states in which perception can manifest. The awake state is privileged in that this coordination is reliably elicited by external visual stimuli.http://www.sciencedirect.com/science/article/pii/S2211124724003450CP: Neuroscience |
| spellingShingle | Adeeti Aggarwal Jennifer Luo Helen Chung Diego Contreras Max B. Kelz Alex Proekt Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states Cell Reports CP: Neuroscience |
| title | Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states |
| title_full | Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states |
| title_fullStr | Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states |
| title_full_unstemmed | Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states |
| title_short | Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states |
| title_sort | neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724003450 |
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