DNA Damage/Repair Management in Cancers
DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA damage occurs, the possibility of generated mutations increases. Genomic insta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/4/1050 |
| _version_ | 1797569792119406592 |
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| author | Jehad F. Alhmoud John F. Woolley Ala-Eddin Al Moustafa Mohammed Imad Malki |
| author_facet | Jehad F. Alhmoud John F. Woolley Ala-Eddin Al Moustafa Mohammed Imad Malki |
| author_sort | Jehad F. Alhmoud |
| collection | DOAJ |
| description | DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA damage occurs, the possibility of generated mutations increases. Genomic instability is one of the most important factors that lead to cancer development. DNA repair pathways perform the essential role of correcting the DNA lesions that occur from DNA damaging agents or carcinogens, thus maintaining genomic stability. Inefficient DNA repair is a critical driving force behind cancer establishment, progression and evolution. A thorough understanding of DNA repair mechanisms in cancer will allow for better therapeutic intervention. In this review we will discuss the relationship between DNA damage/repair mechanisms and cancer, and how we can target these pathways. |
| first_indexed | 2024-03-10T20:16:34Z |
| format | Article |
| id | doaj.art-9d91e6ba6d404a2180ac221cd42b0e00 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:16:34Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9d91e6ba6d404a2180ac221cd42b0e002023-11-19T22:32:30ZengMDPI AGCancers2072-66942020-04-01124105010.3390/cancers12041050DNA Damage/Repair Management in CancersJehad F. Alhmoud0John F. Woolley1Ala-Eddin Al Moustafa2Mohammed Imad Malki3Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, JordanDepartment of Molecular & Clinical Pharmacology, Liverpool University, Liverpool L69 3GE, UKCollege of Medicine, QU Health, Qatar University, Doha P. O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P. O. Box 2713, QatarDNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA damage occurs, the possibility of generated mutations increases. Genomic instability is one of the most important factors that lead to cancer development. DNA repair pathways perform the essential role of correcting the DNA lesions that occur from DNA damaging agents or carcinogens, thus maintaining genomic stability. Inefficient DNA repair is a critical driving force behind cancer establishment, progression and evolution. A thorough understanding of DNA repair mechanisms in cancer will allow for better therapeutic intervention. In this review we will discuss the relationship between DNA damage/repair mechanisms and cancer, and how we can target these pathways.https://www.mdpi.com/2072-6694/12/4/1050DNA damageDNA repair pathwayDNA lesiongenomic instability |
| spellingShingle | Jehad F. Alhmoud John F. Woolley Ala-Eddin Al Moustafa Mohammed Imad Malki DNA Damage/Repair Management in Cancers Cancers DNA damage DNA repair pathway DNA lesion genomic instability |
| title | DNA Damage/Repair Management in Cancers |
| title_full | DNA Damage/Repair Management in Cancers |
| title_fullStr | DNA Damage/Repair Management in Cancers |
| title_full_unstemmed | DNA Damage/Repair Management in Cancers |
| title_short | DNA Damage/Repair Management in Cancers |
| title_sort | dna damage repair management in cancers |
| topic | DNA damage DNA repair pathway DNA lesion genomic instability |
| url | https://www.mdpi.com/2072-6694/12/4/1050 |
| work_keys_str_mv | AT jehadfalhmoud dnadamagerepairmanagementincancers AT johnfwoolley dnadamagerepairmanagementincancers AT alaeddinalmoustafa dnadamagerepairmanagementincancers AT mohammedimadmalki dnadamagerepairmanagementincancers |