Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal CA1 and identified CA1 excitatory neuron sub-...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223007800 |
| _version_ | 1827954190309130240 |
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| author | Lujia Chen Xiaoxiao Lin Qiao Ye Zoran Nenadic Todd C. Holmes Douglas A. Nitz Xiangmin Xu |
| author_facet | Lujia Chen Xiaoxiao Lin Qiao Ye Zoran Nenadic Todd C. Holmes Douglas A. Nitz Xiangmin Xu |
| author_sort | Lujia Chen |
| collection | DOAJ |
| description | Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal CA1 and identified CA1 excitatory neuron sub-populations whose members are active across the same second-long period of time. We identified groups of hippocampal neurons sharing temporally correlated neural calcium activity during behavioral exploration and found that they also organized as clusters in anatomical space. Such clusters vary in membership and activity dynamics with respect to movement in different environments, but also appear during immobility in the dark suggesting an internal dynamic. The strong covariance between dynamics and anatomical location within the CA1 sub-region reveals a previously unrecognized form of topographic representation in hippocampus that may guide generation of hippocampal sequences across time and therefore organize the content of episodic memory. |
| first_indexed | 2024-04-09T14:26:17Z |
| format | Article |
| id | doaj.art-9d92c0cd42944b678ccdd98f426621bd |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T14:26:17Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-9d92c0cd42944b678ccdd98f426621bd2023-05-04T04:13:02ZengElsevieriScience2589-00422023-05-01265106703Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 regionLujia Chen0Xiaoxiao Lin1Qiao Ye2Zoran Nenadic3Todd C. Holmes4Douglas A. Nitz5Xiangmin Xu6Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA 92697-1275, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697-2715, USA; The Center for Neural Circuit Mapping, University of California, Irvine, Irvine, CA 92697, USADepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA 92697-1275, USA; The Center for Neural Circuit Mapping, University of California, Irvine, Irvine, CA 92697, USADepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA 92697-1275, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697-2715, USA; The Center for Neural Circuit Mapping, University of California, Irvine, Irvine, CA 92697, USADepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697-2715, USA; The Center for Neural Circuit Mapping, University of California, Irvine, Irvine, CA 92697, USADepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697- 4560, USA; The Center for Neural Circuit Mapping, University of California, Irvine, Irvine, CA 92697, USADepartment of Cognitive Science, University of California, La Jolla, La Jolla, CA 92093, San Diego; The Center for Neural Circuit Mapping, University of California, Irvine, Irvine, CA 92697, USA; Corresponding authorDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA 92697-1275, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697-2715, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697-4025, USA; Department of Computer Science, University of California, Irvine, Irvine, CA 92697-3435, USA; The Center for Neural Circuit Mapping, University of California, Irvine, Irvine, CA 92697, USA; Corresponding authorSummary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal CA1 and identified CA1 excitatory neuron sub-populations whose members are active across the same second-long period of time. We identified groups of hippocampal neurons sharing temporally correlated neural calcium activity during behavioral exploration and found that they also organized as clusters in anatomical space. Such clusters vary in membership and activity dynamics with respect to movement in different environments, but also appear during immobility in the dark suggesting an internal dynamic. The strong covariance between dynamics and anatomical location within the CA1 sub-region reveals a previously unrecognized form of topographic representation in hippocampus that may guide generation of hippocampal sequences across time and therefore organize the content of episodic memory.http://www.sciencedirect.com/science/article/pii/S2589004223007800NeuroscienceMolecular neuroscienceCellular neuroscience |
| spellingShingle | Lujia Chen Xiaoxiao Lin Qiao Ye Zoran Nenadic Todd C. Holmes Douglas A. Nitz Xiangmin Xu Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region iScience Neuroscience Molecular neuroscience Cellular neuroscience |
| title | Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region |
| title_full | Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region |
| title_fullStr | Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region |
| title_full_unstemmed | Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region |
| title_short | Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region |
| title_sort | anatomical organization of temporally correlated neural calcium activity in the hippocampal ca1 region |
| topic | Neuroscience Molecular neuroscience Cellular neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223007800 |
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