Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells.

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells.

Vascular endothelial growth factor (VEGF) is a powerful regulator of neovascularization. VEGF binding to its cognate receptor, VEGFR2, activates a number of signaling pathways including ERK1/2. Activation of ERK1/2 is experimentally shown to involve sphingosine kinase 1 (SphK1) activation and its ca...

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Bibliographic Details
Main Authors: Hojjat Bazzazi, Aleksander S Popel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-02-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5298229?pdf=render

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