Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study
IntroductionDairy products have long been regarded as a controversial nutrient for the skin. However, a clear demonstration of donkey milk (DM) on skincare is required.MethodsIn this study, spectrum and chemical component analyses were applied to DM. Then, the effects of DM on UVB-induced skin barri...
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Frontiers Media S.A.
2023-03-01
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Series: | Frontiers in Nutrition |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1121498/full |
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author | Anqi Li Anqi Li Anqi Li Hailun He Hailun He Hailun He Yanjing Chen Yanjing Chen Yanjing Chen Feng Liao Jie Tang Jie Tang Li Li Yumei Fan Li Li Li Li Li Li Lidan Xiong Lidan Xiong |
author_facet | Anqi Li Anqi Li Anqi Li Hailun He Hailun He Hailun He Yanjing Chen Yanjing Chen Yanjing Chen Feng Liao Jie Tang Jie Tang Li Li Yumei Fan Li Li Li Li Li Li Lidan Xiong Lidan Xiong |
author_sort | Anqi Li |
collection | DOAJ |
description | IntroductionDairy products have long been regarded as a controversial nutrient for the skin. However, a clear demonstration of donkey milk (DM) on skincare is required.MethodsIn this study, spectrum and chemical component analyses were applied to DM. Then, the effects of DM on UVB-induced skin barrier damage and melanin pigmentation were first evaluated in vitro and in vivo. Cell survival, animal models, and expression of filaggrin (FLG) were determined to confirm the effect of DM on UVB-induced skin barrier damage. Melanogenesis and tyrosinase (TYR) activity were assessed after UVB irradiation to clarify the effect of DM on whitening activities. Further, a network pharmacology method was applied to study the interaction between DM ingredients and UVB-induced skin injury. Meanwhile, an analysis of the melanogenesis molecular target network was developed and validated to predict the melanogenesis regulators in DM.ResultsDM was rich in cholesterols, fatty acids, vitamins and amino acids. The results of evaluation of whitening activities in vitro and in vivo indicated that DM had a potent inhibitory effect on melanin synthesis. The results of effects of DM on UVB‑induced skin barrier damage indicated that DM inhibited UVB-induced injury and restored skin barrier function via up-regulation expression of FLG (filaggrin). The pharmacological network of DM showed that DM regulated steroid biosynthesis and fatty acid metabolism in keratinocytes and 64 melanin targets which the main contributing role of DM might target melanogenesis, cell adhesion molecules (CAMs), and Tumor necrosis factor (TNF) pathway.DiscussionThese results highlight the potential use of DM as a promising agent for whitening and anti-photoaging applications. |
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last_indexed | 2024-04-10T05:13:57Z |
publishDate | 2023-03-01 |
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series | Frontiers in Nutrition |
spelling | doaj.art-9d9766f43f5f496e9c4ee534f12399bd2023-03-09T05:32:45ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11214981121498Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation studyAnqi Li0Anqi Li1Anqi Li2Hailun He3Hailun He4Hailun He5Yanjing Chen6Yanjing Chen7Yanjing Chen8Feng Liao9Jie Tang10Jie Tang11Li Li12Yumei Fan13Li Li14Li Li15Li Li16Lidan Xiong17Lidan Xiong18Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaNMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaNMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaNMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaNational Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E-E-Jiao Co. Ltd., Shandong, ChinaCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaNMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, ChinaLaboratory of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaNational Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E-E-Jiao Co. Ltd., Shandong, ChinaCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaNMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, ChinaDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaNMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, Chengdu, ChinaIntroductionDairy products have long been regarded as a controversial nutrient for the skin. However, a clear demonstration of donkey milk (DM) on skincare is required.MethodsIn this study, spectrum and chemical component analyses were applied to DM. Then, the effects of DM on UVB-induced skin barrier damage and melanin pigmentation were first evaluated in vitro and in vivo. Cell survival, animal models, and expression of filaggrin (FLG) were determined to confirm the effect of DM on UVB-induced skin barrier damage. Melanogenesis and tyrosinase (TYR) activity were assessed after UVB irradiation to clarify the effect of DM on whitening activities. Further, a network pharmacology method was applied to study the interaction between DM ingredients and UVB-induced skin injury. Meanwhile, an analysis of the melanogenesis molecular target network was developed and validated to predict the melanogenesis regulators in DM.ResultsDM was rich in cholesterols, fatty acids, vitamins and amino acids. The results of evaluation of whitening activities in vitro and in vivo indicated that DM had a potent inhibitory effect on melanin synthesis. The results of effects of DM on UVB‑induced skin barrier damage indicated that DM inhibited UVB-induced injury and restored skin barrier function via up-regulation expression of FLG (filaggrin). The pharmacological network of DM showed that DM regulated steroid biosynthesis and fatty acid metabolism in keratinocytes and 64 melanin targets which the main contributing role of DM might target melanogenesis, cell adhesion molecules (CAMs), and Tumor necrosis factor (TNF) pathway.DiscussionThese results highlight the potential use of DM as a promising agent for whitening and anti-photoaging applications.https://www.frontiersin.org/articles/10.3389/fnut.2023.1121498/fulldonkey milkUVBskin barrier functionmelanogenesisnetwork pharmacology |
spellingShingle | Anqi Li Anqi Li Anqi Li Hailun He Hailun He Hailun He Yanjing Chen Yanjing Chen Yanjing Chen Feng Liao Jie Tang Jie Tang Li Li Yumei Fan Li Li Li Li Li Li Lidan Xiong Lidan Xiong Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study Frontiers in Nutrition donkey milk UVB skin barrier function melanogenesis network pharmacology |
title | Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study |
title_full | Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study |
title_fullStr | Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study |
title_full_unstemmed | Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study |
title_short | Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study |
title_sort | effects of donkey milk on uvb induced skin barrier damage and melanin pigmentation a network pharmacology and experimental validation study |
topic | donkey milk UVB skin barrier function melanogenesis network pharmacology |
url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1121498/full |
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