Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature
Xinchao Liu,1,* Hao Xing,2,3,* Jing Lin,1,3,* Jian Sun,4 Yu Wang,3 Yaxu Liu,5 Wei Cao,1,6 Zhengyin Liu,1 Taisheng Li1,6,7 1Department of Infectious Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, Peop...
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| Format: | Article |
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Dove Medical Press
2024-02-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/coexisting-of-primary-central-nervous-system-lymphoma-and-talaromyces--peer-reviewed-fulltext-article-IDR |
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| author | Liu X Xing H Lin J Sun J Wang Y Liu Y Cao W Liu Z Li T |
| author_facet | Liu X Xing H Lin J Sun J Wang Y Liu Y Cao W Liu Z Li T |
| author_sort | Liu X |
| collection | DOAJ |
| description | Xinchao Liu,1,* Hao Xing,2,3,* Jing Lin,1,3,* Jian Sun,4 Yu Wang,3 Yaxu Liu,5 Wei Cao,1,6 Zhengyin Liu,1 Taisheng Li1,6,7 1Department of Infectious Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 3Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 5Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 6State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 7Tsinghua-Peking Center for Life Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Taisheng Li, Email litsh@263.netBackground: Talaromyces marneffei is prevalent in South Asia. Latent Talaromyces marneffei infection of travellers make the diagnosis difficult. There are similarities in clinical manifestations between Talaromyces marneffei infection and lymphoma. Brain abscess is a rare form of Talaromyces marneffei infection.Case Presentation: We reported a very rare case of a 19-year-old man with HIV infection who suffered from a brain mass and lymphadenopathy. His blood culture, bone marrow culture and sputum culture all grew Talaromyces marneffei. One month after treatment with voriconazole, the symptoms improved except brain mass. Surgical incision of the brain mass showed a compact mass, and pathological analysis showed the coexisting Talaromyces marneffei abscess and lymphoma. The patient is currently in a stable condition after receiving antifungal therapy and chemotherapy.Conclusion: Based on a case report of a traveller who suffered from a brain mass of Talaromyces marneffei abscess and lymphoma after a visit to an endemic area, this review summarized the cases where there was confusion between lymphoma and the brain abscess of Talaromyces marneffei. Talaromyces marneffei infection can be found globally due to the increasing number of international travels. Talaromyces marneffei infection and lymphoma had similar characteristics which is easy to misdiagnose in clinic. Infection may also be accompanied by tumors, especially in patients infected with HIV. The manifestations and imaging of brain abscess of Talaromyces marneffei were not characteristic in different patients.Keywords: Talaromyces marneffei, lymphoma, misdiagnose, HIV, travel |
| first_indexed | 2024-03-07T22:58:27Z |
| format | Article |
| id | doaj.art-9d98ca9a35104f2293802632c29e41b2 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-07T22:58:27Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-9d98ca9a35104f2293802632c29e41b22024-02-22T18:28:24ZengDove Medical PressInfection and Drug Resistance1178-69732024-02-01Volume 1770971890634Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the LiteratureLiu XXing HLin JSun JWang YLiu YCao WLiu ZLi TXinchao Liu,1,* Hao Xing,2,3,* Jing Lin,1,3,* Jian Sun,4 Yu Wang,3 Yaxu Liu,5 Wei Cao,1,6 Zhengyin Liu,1 Taisheng Li1,6,7 1Department of Infectious Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 3Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 5Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of China; 6State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 7Tsinghua-Peking Center for Life Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Taisheng Li, Email litsh@263.netBackground: Talaromyces marneffei is prevalent in South Asia. Latent Talaromyces marneffei infection of travellers make the diagnosis difficult. There are similarities in clinical manifestations between Talaromyces marneffei infection and lymphoma. Brain abscess is a rare form of Talaromyces marneffei infection.Case Presentation: We reported a very rare case of a 19-year-old man with HIV infection who suffered from a brain mass and lymphadenopathy. His blood culture, bone marrow culture and sputum culture all grew Talaromyces marneffei. One month after treatment with voriconazole, the symptoms improved except brain mass. Surgical incision of the brain mass showed a compact mass, and pathological analysis showed the coexisting Talaromyces marneffei abscess and lymphoma. The patient is currently in a stable condition after receiving antifungal therapy and chemotherapy.Conclusion: Based on a case report of a traveller who suffered from a brain mass of Talaromyces marneffei abscess and lymphoma after a visit to an endemic area, this review summarized the cases where there was confusion between lymphoma and the brain abscess of Talaromyces marneffei. Talaromyces marneffei infection can be found globally due to the increasing number of international travels. Talaromyces marneffei infection and lymphoma had similar characteristics which is easy to misdiagnose in clinic. Infection may also be accompanied by tumors, especially in patients infected with HIV. The manifestations and imaging of brain abscess of Talaromyces marneffei were not characteristic in different patients.Keywords: Talaromyces marneffei, lymphoma, misdiagnose, HIV, travelhttps://www.dovepress.com/coexisting-of-primary-central-nervous-system-lymphoma-and-talaromyces--peer-reviewed-fulltext-article-IDRtalaromyces marneffeilymphomamisdiagnosehivtravel |
| spellingShingle | Liu X Xing H Lin J Sun J Wang Y Liu Y Cao W Liu Z Li T Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature Infection and Drug Resistance talaromyces marneffei lymphoma misdiagnose hiv travel |
| title | Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature |
| title_full | Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature |
| title_fullStr | Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature |
| title_full_unstemmed | Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature |
| title_short | Coexisting of Primary Central Nervous System Lymphoma and Talaromyces marneffei Brain Abscess in an AIDS Patient, A Case Report and Review of the Literature |
| title_sort | coexisting of primary central nervous system lymphoma and talaromyces marneffei brain abscess in an aids patient a case report and review of the literature |
| topic | talaromyces marneffei lymphoma misdiagnose hiv travel |
| url | https://www.dovepress.com/coexisting-of-primary-central-nervous-system-lymphoma-and-talaromyces--peer-reviewed-fulltext-article-IDR |
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