Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke?
Background: Intracranial aneurysms (IAs) are found in around 3–4% of elderly people. The authors attempt to answer why IAs develop exclusively in the circle of Willis (CW) and why IAs in the frontal cerebral arteries are unusually frequent in men. Methods: The location and frequency of IAs were anal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Vascular Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2813-2475/2/2/16 |
| _version_ | 1797593934432567296 |
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| author | Ulrich Barz Almut Schreiber Helmut Barz |
| author_facet | Ulrich Barz Almut Schreiber Helmut Barz |
| author_sort | Ulrich Barz |
| collection | DOAJ |
| description | Background: Intracranial aneurysms (IAs) are found in around 3–4% of elderly people. The authors attempt to answer why IAs develop exclusively in the circle of Willis (CW) and why IAs in the frontal cerebral arteries are unusually frequent in men. Methods: The location and frequency of IAs were analyzed using relevant publications (MEDLINE and PubMed). Results: It is suggested that superposed blood pulse waves may have an influence on the development of IAs. The superposition of blood pulse waves is caused by the meeting of the bilateral cerebral arteries in the CW. The predominance of IAs in women is striking (about 1.7:1). However, IAs in the anterior cerebral arteries and anterior communicating artery are significantly more common in men than in women (approximately 1.8:1). The authors hypothesize that greater nicotine abuse in men may explain this phenomenon. Cigarette smoke apparently reaches the anterior cerebral arteries via the olfactory pathway. Conclusion: It seems possible that superposed pulse waves are a substantial factor in the occurrence of IAs. The toxic effects of tobacco smoke appear to have greater impact on IA development than the sex-specific influences that are responsible for the predominance of IAs in women. |
| first_indexed | 2024-03-11T02:15:34Z |
| format | Article |
| id | doaj.art-9d9983cb6b4f4631854eb696d6d4bad9 |
| institution | Directory Open Access Journal |
| issn | 2813-2475 |
| language | English |
| last_indexed | 2024-03-11T02:15:34Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Vascular Diseases |
| spelling | doaj.art-9d9983cb6b4f4631854eb696d6d4bad92023-11-18T11:12:30ZengMDPI AGJournal of Vascular Diseases2813-24752023-05-012222222910.3390/jvd2020016Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke?Ulrich Barz0Almut Schreiber1Helmut Barz2Clinic for Internal Medicine, Helios Medical Center Pirna, Struppener Str. 13, D-01796 Pirna, GermanyMedical Center for Occupational and Social Hygiene, Fit for Work, Bautzener Landstraße 91, D-01324 Dresden, GermanyDepartment of Neuropathology, Dietrich Bonhoeffer Hospital, D-17022 Neubrandenburg, GermanyBackground: Intracranial aneurysms (IAs) are found in around 3–4% of elderly people. The authors attempt to answer why IAs develop exclusively in the circle of Willis (CW) and why IAs in the frontal cerebral arteries are unusually frequent in men. Methods: The location and frequency of IAs were analyzed using relevant publications (MEDLINE and PubMed). Results: It is suggested that superposed blood pulse waves may have an influence on the development of IAs. The superposition of blood pulse waves is caused by the meeting of the bilateral cerebral arteries in the CW. The predominance of IAs in women is striking (about 1.7:1). However, IAs in the anterior cerebral arteries and anterior communicating artery are significantly more common in men than in women (approximately 1.8:1). The authors hypothesize that greater nicotine abuse in men may explain this phenomenon. Cigarette smoke apparently reaches the anterior cerebral arteries via the olfactory pathway. Conclusion: It seems possible that superposed pulse waves are a substantial factor in the occurrence of IAs. The toxic effects of tobacco smoke appear to have greater impact on IA development than the sex-specific influences that are responsible for the predominance of IAs in women.https://www.mdpi.com/2813-2475/2/2/16intracranial aneurysmcircle of Willissuperposed blood pulse wavesnicotine abusesubarachnoid hemorrhage |
| spellingShingle | Ulrich Barz Almut Schreiber Helmut Barz Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke? Journal of Vascular Diseases intracranial aneurysm circle of Willis superposed blood pulse waves nicotine abuse subarachnoid hemorrhage |
| title | Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke? |
| title_full | Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke? |
| title_fullStr | Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke? |
| title_full_unstemmed | Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke? |
| title_short | Intracranial Aneurysms: Relevance of Superposed Blood Pulse Waves and Tobacco Smoke? |
| title_sort | intracranial aneurysms relevance of superposed blood pulse waves and tobacco smoke |
| topic | intracranial aneurysm circle of Willis superposed blood pulse waves nicotine abuse subarachnoid hemorrhage |
| url | https://www.mdpi.com/2813-2475/2/2/16 |
| work_keys_str_mv | AT ulrichbarz intracranialaneurysmsrelevanceofsuperposedbloodpulsewavesandtobaccosmoke AT almutschreiber intracranialaneurysmsrelevanceofsuperposedbloodpulsewavesandtobaccosmoke AT helmutbarz intracranialaneurysmsrelevanceofsuperposedbloodpulsewavesandtobaccosmoke |