EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis
Viral oncogenes may drive cellular metabolic reprogramming to modulate the normal epithelia cell malignant transformation. Understanding the viral oncogene–mediated signaling transduction dysregulation that involves in metabolic reprogramming may provide new therapeutic targets for virus-associated...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.935205/full |
| _version_ | 1818218247481196544 |
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| author | Tingting Yang Chanping You Shuhui Meng Zhengquan Lai Weipeng Ai Jun Zhang |
| author_facet | Tingting Yang Chanping You Shuhui Meng Zhengquan Lai Weipeng Ai Jun Zhang |
| author_sort | Tingting Yang |
| collection | DOAJ |
| description | Viral oncogenes may drive cellular metabolic reprogramming to modulate the normal epithelia cell malignant transformation. Understanding the viral oncogene–mediated signaling transduction dysregulation that involves in metabolic reprogramming may provide new therapeutic targets for virus-associated cancer treatment. Latent EBV infection and expression of viral oncogenes, including latent membrane proteins 1 and 2 (LMP1/2), and EBV-encoded BamH I-A rightward transcripts (BART) microRNAs (miR-BARTs), have been demonstrated to play fundamental roles in altering host cell metabolism to support nasopharyngeal carcinoma (NPC) pathogenesis. Yet, how do EBV infection and its encoded oncogenes facilitated the metabolic shifting and their roles in NPC carcinogenesis remains unclear. In this review, we will focus on delineating how EBV infection and its encoded oncoproteins altered the metabolic reprograming of infected cells to support their malignances. Furthermore, based on the understanding of the host’s metabolic signaling alterations induced by EBV, we will provide a new perspective on the interplay between EBV infection and these metabolic pathways and offering a potential therapeutic intervention strategy in the treatment of EBV-associated malignant diseases. |
| first_indexed | 2024-12-12T07:20:44Z |
| format | Article |
| id | doaj.art-9d9a82e2f5294fac86e577d868a66c0d |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-12T07:20:44Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-9d9a82e2f5294fac86e577d868a66c0d2022-12-22T00:33:23ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-07-011210.3389/fcimb.2022.935205935205EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal TumorigenesisTingting Yang0Chanping You1Shuhui Meng2Zhengquan Lai3Weipeng Ai4Jun Zhang5Department of Pharmacy, Shenzhen University General Hospital, Shenzhen, ChinaDepartment of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaClinical Medical Research Center, Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine, Shenzhen Engineering Research Center of Autoimmune Disease, Shenzhen People’s Hospital, Shenzhen, ChinaDepartment of Pharmacy, Shenzhen University General Hospital, Shenzhen, ChinaDepartment of Pharmacy, Shenzhen University General Hospital, Shenzhen, ChinaGuangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, ChinaViral oncogenes may drive cellular metabolic reprogramming to modulate the normal epithelia cell malignant transformation. Understanding the viral oncogene–mediated signaling transduction dysregulation that involves in metabolic reprogramming may provide new therapeutic targets for virus-associated cancer treatment. Latent EBV infection and expression of viral oncogenes, including latent membrane proteins 1 and 2 (LMP1/2), and EBV-encoded BamH I-A rightward transcripts (BART) microRNAs (miR-BARTs), have been demonstrated to play fundamental roles in altering host cell metabolism to support nasopharyngeal carcinoma (NPC) pathogenesis. Yet, how do EBV infection and its encoded oncogenes facilitated the metabolic shifting and their roles in NPC carcinogenesis remains unclear. In this review, we will focus on delineating how EBV infection and its encoded oncoproteins altered the metabolic reprograming of infected cells to support their malignances. Furthermore, based on the understanding of the host’s metabolic signaling alterations induced by EBV, we will provide a new perspective on the interplay between EBV infection and these metabolic pathways and offering a potential therapeutic intervention strategy in the treatment of EBV-associated malignant diseases.https://www.frontiersin.org/articles/10.3389/fcimb.2022.935205/fullEBV infectionmetabolic reprogrammingnasopharyngeal carcinomaNPC pathogenesistherapeutic strategies |
| spellingShingle | Tingting Yang Chanping You Shuhui Meng Zhengquan Lai Weipeng Ai Jun Zhang EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis Frontiers in Cellular and Infection Microbiology EBV infection metabolic reprogramming nasopharyngeal carcinoma NPC pathogenesis therapeutic strategies |
| title | EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis |
| title_full | EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis |
| title_fullStr | EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis |
| title_full_unstemmed | EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis |
| title_short | EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis |
| title_sort | ebv infection and its regulated metabolic reprogramming in nasopharyngeal tumorigenesis |
| topic | EBV infection metabolic reprogramming nasopharyngeal carcinoma NPC pathogenesis therapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.935205/full |
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