Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival.
Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 st...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Online Access: | http://europepmc.org/articles/PMC3696098?pdf=render |
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| author | Yu Yao Aden Ka-Yin Chan Zhi Yong Qin Ling Chao Chen Xin Zhang Jesse Chung-Sean Pang Hiu Ming Li Yin Wang Ying Mao Ho-Keung Ng Liang Fu Zhou |
| author_facet | Yu Yao Aden Ka-Yin Chan Zhi Yong Qin Ling Chao Chen Xin Zhang Jesse Chung-Sean Pang Hiu Ming Li Yin Wang Ying Mao Ho-Keung Ng Liang Fu Zhou |
| author_sort | Yu Yao |
| collection | DOAJ |
| description | Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 status at codon 132 of IDH1 and codon 172 of IDH2 by direct sequencing and anti-IDH1-R132H immunohistochemistry in 53 paired samples and their recurrences, including 29 low-grade gliomas, 16 anaplastic gliomas and 8 Glioblastomas. IDH1/IDH2 mutation was detected in 32 primary tumors, with 25 low-grade gliomas and 6 anaplastic gliomas harboring IDH1 mutation and 1 low-grade glioma harboring IDH2 mutation. All of the paired tumors showed consistent IDH1 and IDH2 status. Patients were analyzed according to IDH1 status and tumor-related factors. Malignant progression at recurrence was noted in 22 gliomas and was not associated with IDH1 mutation. Survival analysis revealed patients with IDH1 mutated gliomas had a significantly longer progression-free survival (PFS) and overall survival (OS). In conclusion, this study demonstrated a strong tendency of IDH1/IDH2 status being consistent during progression of glioma. IDH1 mutation was not a predictive marker for malignant progression and it was a potential prognostic marker for gliomas of Chinese patients. |
| first_indexed | 2024-12-13T06:28:19Z |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T06:28:19Z |
| publishDate | 2013-01-01 |
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| spelling | doaj.art-9d9aaf893b9d4eb29b225434fa808bac2022-12-21T23:56:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6742110.1371/journal.pone.0067421Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival.Yu YaoAden Ka-Yin ChanZhi Yong QinLing Chao ChenXin ZhangJesse Chung-Sean PangHiu Ming LiYin WangYing MaoHo-Keung NgLiang Fu ZhouRecurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 status at codon 132 of IDH1 and codon 172 of IDH2 by direct sequencing and anti-IDH1-R132H immunohistochemistry in 53 paired samples and their recurrences, including 29 low-grade gliomas, 16 anaplastic gliomas and 8 Glioblastomas. IDH1/IDH2 mutation was detected in 32 primary tumors, with 25 low-grade gliomas and 6 anaplastic gliomas harboring IDH1 mutation and 1 low-grade glioma harboring IDH2 mutation. All of the paired tumors showed consistent IDH1 and IDH2 status. Patients were analyzed according to IDH1 status and tumor-related factors. Malignant progression at recurrence was noted in 22 gliomas and was not associated with IDH1 mutation. Survival analysis revealed patients with IDH1 mutated gliomas had a significantly longer progression-free survival (PFS) and overall survival (OS). In conclusion, this study demonstrated a strong tendency of IDH1/IDH2 status being consistent during progression of glioma. IDH1 mutation was not a predictive marker for malignant progression and it was a potential prognostic marker for gliomas of Chinese patients.http://europepmc.org/articles/PMC3696098?pdf=render |
| spellingShingle | Yu Yao Aden Ka-Yin Chan Zhi Yong Qin Ling Chao Chen Xin Zhang Jesse Chung-Sean Pang Hiu Ming Li Yin Wang Ying Mao Ho-Keung Ng Liang Fu Zhou Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. PLoS ONE |
| title | Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. |
| title_full | Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. |
| title_fullStr | Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. |
| title_full_unstemmed | Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. |
| title_short | Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival. |
| title_sort | mutation analysis of idh1 in paired gliomas revealed idh1 mutation was not associated with malignant progression but predicted longer survival |
| url | http://europepmc.org/articles/PMC3696098?pdf=render |
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