Relation of serum resistin to subclinical atherosclerosis in multiple sclerosis
Abstract Background Resistin is a small protein that has pro-inflammatory and atherogenic effects. This study aimed to evaluate the level of serum resistin as a marker of subclinical atherosclerosis in multiple sclerosis (MS) sufferers. 114 MS sufferers and 114 age, sex and body mass index matched c...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-10-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00733-4 |
| _version_ | 1797577389124878336 |
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| author | Rania S. Nageeb Heba F. Tantawy Amal Fawzy Marwa Abdel-monem Ateya |
| author_facet | Rania S. Nageeb Heba F. Tantawy Amal Fawzy Marwa Abdel-monem Ateya |
| author_sort | Rania S. Nageeb |
| collection | DOAJ |
| description | Abstract Background Resistin is a small protein that has pro-inflammatory and atherogenic effects. This study aimed to evaluate the level of serum resistin as a marker of subclinical atherosclerosis in multiple sclerosis (MS) sufferers. 114 MS sufferers and 114 age, sex and body mass index matched controls were enrolled in this study, subjected to detailed history taking, general, neurological examination, assessment of anthropometric measurements, serum resistin level, and carotid duplex to asses subclinical atherosclerosis. Results MS sufferers showed a higher cholesterol, and triglycerides levels as compared to controls. Progressive MS sufferers (SPMS, and PPMS) showed a higher cholesterol level as compared to RRMS sufferers. SPMS sufferers showed a higher cholesterol level as compared to PPMS sufferers. RRMS sufferers showed a higher triglycerides level as compared to progressive MS sufferers. Sufferers had significantly higher mean levels of resistin and right carotid intimal medial thickness (CIMT) as compared to controls. There was a significant positive correlation in MS sufferers between serum resistin and the following parameters: age, and disease duration, body mass index, triglycerides, cholesterol and low-density lipoprotein. There were significant positive correlations between carotid intimal medial thickness and body mass index, disease duration, age, expanded disability status scale, levels of triglycerides, low-density lipoprotein, and cholesterol. The risk factors of subclinical atherosclerosis in MS sufferers were higher mean levels of resistin, triglycerides, low-density lipoprotein, cholesterol, and disease duration. Subclinical atherosclerosis in MS sufferers was significantly associated with higher mean levels of resistin, and triglycerides. Conclusions Higher mean levels of resistin might reflect the predisposition to subclinical atherosclerosis in MS sufferers. |
| first_indexed | 2024-03-10T22:07:33Z |
| format | Article |
| id | doaj.art-9d9b29a5f8f64bf4a5fe68738ed18ac2 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-03-10T22:07:33Z |
| publishDate | 2023-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-9d9b29a5f8f64bf4a5fe68738ed18ac22023-11-19T12:44:49ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292023-10-015911810.1186/s41983-023-00733-4Relation of serum resistin to subclinical atherosclerosis in multiple sclerosisRania S. Nageeb0Heba F. Tantawy1Amal Fawzy2Marwa Abdel-monem Ateya3Faculty of Medicine, Zagazig UniversityFaculty of Medicine, Zagazig UniversityFaculty of Medicine, Zagazig UniversityFaculty of Medicine, Zagazig UniversityAbstract Background Resistin is a small protein that has pro-inflammatory and atherogenic effects. This study aimed to evaluate the level of serum resistin as a marker of subclinical atherosclerosis in multiple sclerosis (MS) sufferers. 114 MS sufferers and 114 age, sex and body mass index matched controls were enrolled in this study, subjected to detailed history taking, general, neurological examination, assessment of anthropometric measurements, serum resistin level, and carotid duplex to asses subclinical atherosclerosis. Results MS sufferers showed a higher cholesterol, and triglycerides levels as compared to controls. Progressive MS sufferers (SPMS, and PPMS) showed a higher cholesterol level as compared to RRMS sufferers. SPMS sufferers showed a higher cholesterol level as compared to PPMS sufferers. RRMS sufferers showed a higher triglycerides level as compared to progressive MS sufferers. Sufferers had significantly higher mean levels of resistin and right carotid intimal medial thickness (CIMT) as compared to controls. There was a significant positive correlation in MS sufferers between serum resistin and the following parameters: age, and disease duration, body mass index, triglycerides, cholesterol and low-density lipoprotein. There were significant positive correlations between carotid intimal medial thickness and body mass index, disease duration, age, expanded disability status scale, levels of triglycerides, low-density lipoprotein, and cholesterol. The risk factors of subclinical atherosclerosis in MS sufferers were higher mean levels of resistin, triglycerides, low-density lipoprotein, cholesterol, and disease duration. Subclinical atherosclerosis in MS sufferers was significantly associated with higher mean levels of resistin, and triglycerides. Conclusions Higher mean levels of resistin might reflect the predisposition to subclinical atherosclerosis in MS sufferers.https://doi.org/10.1186/s41983-023-00733-4Multiple sclerosisResistinAtherosclerosisCarotid intimal–medial thicknessCarotid duplex and lipid profile |
| spellingShingle | Rania S. Nageeb Heba F. Tantawy Amal Fawzy Marwa Abdel-monem Ateya Relation of serum resistin to subclinical atherosclerosis in multiple sclerosis The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Multiple sclerosis Resistin Atherosclerosis Carotid intimal–medial thickness Carotid duplex and lipid profile |
| title | Relation of serum resistin to subclinical atherosclerosis in multiple sclerosis |
| title_full | Relation of serum resistin to subclinical atherosclerosis in multiple sclerosis |
| title_fullStr | Relation of serum resistin to subclinical atherosclerosis in multiple sclerosis |
| title_full_unstemmed | Relation of serum resistin to subclinical atherosclerosis in multiple sclerosis |
| title_short | Relation of serum resistin to subclinical atherosclerosis in multiple sclerosis |
| title_sort | relation of serum resistin to subclinical atherosclerosis in multiple sclerosis |
| topic | Multiple sclerosis Resistin Atherosclerosis Carotid intimal–medial thickness Carotid duplex and lipid profile |
| url | https://doi.org/10.1186/s41983-023-00733-4 |
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