Systems Genetic Identification of Mitochondrion-Associated Alzheimer’s Disease Genes and Implications for Disease Risk Prediction

Systems Genetic Identification of Mitochondrion-Associated Alzheimer’s Disease Genes and Implications for Disease Risk Prediction

Cumulative evidence has revealed the association between mitochondrial dysfunction and Alzheimer’s disease (AD). Because the number of mitochondrial genes is very limited, the mitochondrial pathogenesis of AD must involve certain nuclear genes. In this study, we employed systems genetic methods to i...

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Bibliographic Details
Main Authors: Xuan Xu, Hui Wang, David A. Bennett, Qing-Ye Zhang, Gang Wang, Hong-Yu Zhang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
Alzheimer’s disease
mitochondria
association studies in genetics
epistasis
weighted gene co-expression network analysis
Online Access:https://www.mdpi.com/2227-9059/10/8/1782

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