Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development
Abstract Background Antibiotic exposure in pregnancy is associated with reduced microbiome diversity in the infant gut. Given that recent research has shown that early microbiome health can impact child socioemotional development, we examined the relationship between prenatal antibiotic exposure in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | JCPP Advances |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcv2.12066 |
| _version_ | 1811342456667504640 |
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| author | Adi Fish‐Williamson Jennifer Hahn‐Holbrook Mark Hobbs Jan Wallander Susan M. B. Morton |
| author_facet | Adi Fish‐Williamson Jennifer Hahn‐Holbrook Mark Hobbs Jan Wallander Susan M. B. Morton |
| author_sort | Adi Fish‐Williamson |
| collection | DOAJ |
| description | Abstract Background Antibiotic exposure in pregnancy is associated with reduced microbiome diversity in the infant gut. Given that recent research has shown that early microbiome health can impact child socioemotional development, we examined the relationship between prenatal antibiotic exposure in pregnancy and childhood socioemotional developmental outcomes using a large, nationally representative longitudinal dataset. Methods A sample of 4800 diverse families were assessed from the population cohort of the Growing Up in New Zealand Study (GUiNZ), which prospectively follows children starting in the last trimester of pregnancy into early childhood. Socioemotional development was measured using a composite score derived from seven commonly used socioemotional tasks administered between 9 months and 4.5 years of child age, addressing emotional expression understanding, regulation of emotions and behavior, and social problem solving and relationship skills. A national comprehensive pharmaceutical database was used to determine children's prenatal antibiotic exposure. Multivariate linear regressions models were used to examine the effects of the timing (trimester) and dosage (number of courses) of prenatal antibiotic exposure on socioemotional development, with and without statistically adjusting for confounding factors addressing maternal health, socioeconomic status, maternal age, and child sex. Results In unadjusted analyses, antibiotic exposure was inversely associated with child socioemotional development. However, after statistically adjusting for important confounds, socioemotional development was not associated with prenatal antibiotic exposure at any dosage or trimester of pregnancy (all β ≤ −0.02). Conclusion Prenatal antibiotic exposure does not appear to impact early childhood socioemotional development. Maternal health and sociodemographic factors are confounded with antibiotic exposure and socioemotional development, a fact that should be considered in future research examining the effects of prenatal antibiotic exposure on child health. These findings may be reassuring to families who are concerned about the long‐term effects of antibiotics in pregnancy on child health outcomes. |
| first_indexed | 2024-04-13T19:11:21Z |
| format | Article |
| id | doaj.art-9d9bc85930ee4f84a56d350b45c6b5c8 |
| institution | Directory Open Access Journal |
| issn | 2692-9384 |
| language | English |
| last_indexed | 2024-04-13T19:11:21Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | JCPP Advances |
| spelling | doaj.art-9d9bc85930ee4f84a56d350b45c6b5c82022-12-22T02:33:50ZengWileyJCPP Advances2692-93842022-06-0122n/an/a10.1002/jcv2.12066Prenatal antibiotic exposure in pregnancy and early childhood socioemotional developmentAdi Fish‐Williamson0Jennifer Hahn‐Holbrook1Mark Hobbs2Jan Wallander3Susan M. B. Morton4Department of psychological sciences University of California Merced Merced California USADepartment of psychological sciences University of California Merced Merced California USAAuckland City Hospital Auckland New ZealandDepartment of psychological sciences University of California Merced Merced California USAGrowing Up in New Zealand, Centre for Longitudinal Research – He Ara Ki Mua The University of Auckland Auckland New ZealandAbstract Background Antibiotic exposure in pregnancy is associated with reduced microbiome diversity in the infant gut. Given that recent research has shown that early microbiome health can impact child socioemotional development, we examined the relationship between prenatal antibiotic exposure in pregnancy and childhood socioemotional developmental outcomes using a large, nationally representative longitudinal dataset. Methods A sample of 4800 diverse families were assessed from the population cohort of the Growing Up in New Zealand Study (GUiNZ), which prospectively follows children starting in the last trimester of pregnancy into early childhood. Socioemotional development was measured using a composite score derived from seven commonly used socioemotional tasks administered between 9 months and 4.5 years of child age, addressing emotional expression understanding, regulation of emotions and behavior, and social problem solving and relationship skills. A national comprehensive pharmaceutical database was used to determine children's prenatal antibiotic exposure. Multivariate linear regressions models were used to examine the effects of the timing (trimester) and dosage (number of courses) of prenatal antibiotic exposure on socioemotional development, with and without statistically adjusting for confounding factors addressing maternal health, socioeconomic status, maternal age, and child sex. Results In unadjusted analyses, antibiotic exposure was inversely associated with child socioemotional development. However, after statistically adjusting for important confounds, socioemotional development was not associated with prenatal antibiotic exposure at any dosage or trimester of pregnancy (all β ≤ −0.02). Conclusion Prenatal antibiotic exposure does not appear to impact early childhood socioemotional development. Maternal health and sociodemographic factors are confounded with antibiotic exposure and socioemotional development, a fact that should be considered in future research examining the effects of prenatal antibiotic exposure on child health. These findings may be reassuring to families who are concerned about the long‐term effects of antibiotics in pregnancy on child health outcomes.https://doi.org/10.1002/jcv2.12066antibioticsprenatalsocioemotional development |
| spellingShingle | Adi Fish‐Williamson Jennifer Hahn‐Holbrook Mark Hobbs Jan Wallander Susan M. B. Morton Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development JCPP Advances antibiotics prenatal socioemotional development |
| title | Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development |
| title_full | Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development |
| title_fullStr | Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development |
| title_full_unstemmed | Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development |
| title_short | Prenatal antibiotic exposure in pregnancy and early childhood socioemotional development |
| title_sort | prenatal antibiotic exposure in pregnancy and early childhood socioemotional development |
| topic | antibiotics prenatal socioemotional development |
| url | https://doi.org/10.1002/jcv2.12066 |
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