The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytology
Routine calcitonin measurement in patients with nodular thyroid disease is rather controversial. The aim of this study was to evaluate the contribution of serum calcitonin measurement in the diagnostic evaluation of thyroid nodules with insufficient, indeterminate, or suspicious cytology. Out of 16...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2022-02-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/5756 |
| _version_ | 1797261310790991872 |
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| author | Muhammed Erkam Sencar Sema Hepsen Murat Çalapkulu Hayri Bostan Davut Sakiz Ilknur Ozturk Unsal Hakan Duger Muhammed Kizilgul Bekir Ucan Tugba Taskin Turkmenoglu Mustafa Ozbek Erman Cakal |
| author_facet | Muhammed Erkam Sencar Sema Hepsen Murat Çalapkulu Hayri Bostan Davut Sakiz Ilknur Ozturk Unsal Hakan Duger Muhammed Kizilgul Bekir Ucan Tugba Taskin Turkmenoglu Mustafa Ozbek Erman Cakal |
| author_sort | Muhammed Erkam Sencar |
| collection | DOAJ |
| description |
Routine calcitonin measurement in patients with nodular thyroid disease is rather controversial. The aim of this study was to evaluate the contribution of serum calcitonin measurement in the diagnostic evaluation of thyroid nodules with insufficient, indeterminate, or suspicious cytology. Out of 1668 patients who underwent thyroidectomy with the diagnosis of nodular thyroid disease and were screened, 873 patients with insufficient, indeterminate, or suspicious fine needle aspiration biopsy results were included in the study. From the total number of patients in this study, 10 (1.1%) were diagnosed as medullary thyroid cancer (MTC) using histopathology. The calcitonin level was detected to be above the assay-specific cut-off in 23 (2.6%) patients ranging between 6.5 - 4450 pg/mL. While hypercalcitoninemia was detected in all 10 MTC patients, a false positive elevation of serum calcitonin was detected in 13 patients (1.5%). Of the MTC group, 7 patients had cytology results that were suspicious for malignancy (Bethesda V), one patient’s cytology showed atypia of undetermined significance (Bethesda III) and two patient’s cytology results were suspicious for follicular neoplasm (Bethesda IV). Among the cases with non-diagnostic cytology (Bethesda I), none of the patients were diagnosed with MTC. In conclusion, routine serum calcitonin measurement can be performed in selected cases rather than in all nodular thyroid patients. While it is reasonable to perform routine calcitonin measurement in patients with Bethesda IV and Bethesda V, this measurement was not useful in Bethesda I patients. In Bethesda III patients, patient-based decisions can be made according to their calcitonin measurement.
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| first_indexed | 2024-04-24T23:39:11Z |
| format | Article |
| id | doaj.art-9d9c314299124b73af5d9e009af415d5 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:11Z |
| publishDate | 2022-02-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-9d9c314299124b73af5d9e009af415d52024-03-15T13:44:01ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2022-02-0122110.17305/bjbms.2021.5756The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytologyMuhammed Erkam Sencar0https://orcid.org/0000-0001-5581-4886Sema Hepsen1Murat Çalapkulu2https://orcid.org/0000-0002-7445-2275Hayri Bostan3https://orcid.org/0000-0002-4957-9856Davut Sakiz4Ilknur Ozturk Unsal5https://orcid.org/0000-0003-3999-6426Hakan Duger6Muhammed Kizilgul7https://orcid.org/0000-0002-8468-9196Bekir Ucan8Tugba Taskin Turkmenoglu9https://orcid.org/0000-0001-6314-2928 Mustafa Ozbek10Erman Cakal11https://orcid.org/0000-0003-4455-7276Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Pathology, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey Routine calcitonin measurement in patients with nodular thyroid disease is rather controversial. The aim of this study was to evaluate the contribution of serum calcitonin measurement in the diagnostic evaluation of thyroid nodules with insufficient, indeterminate, or suspicious cytology. Out of 1668 patients who underwent thyroidectomy with the diagnosis of nodular thyroid disease and were screened, 873 patients with insufficient, indeterminate, or suspicious fine needle aspiration biopsy results were included in the study. From the total number of patients in this study, 10 (1.1%) were diagnosed as medullary thyroid cancer (MTC) using histopathology. The calcitonin level was detected to be above the assay-specific cut-off in 23 (2.6%) patients ranging between 6.5 - 4450 pg/mL. While hypercalcitoninemia was detected in all 10 MTC patients, a false positive elevation of serum calcitonin was detected in 13 patients (1.5%). Of the MTC group, 7 patients had cytology results that were suspicious for malignancy (Bethesda V), one patient’s cytology showed atypia of undetermined significance (Bethesda III) and two patient’s cytology results were suspicious for follicular neoplasm (Bethesda IV). Among the cases with non-diagnostic cytology (Bethesda I), none of the patients were diagnosed with MTC. In conclusion, routine serum calcitonin measurement can be performed in selected cases rather than in all nodular thyroid patients. While it is reasonable to perform routine calcitonin measurement in patients with Bethesda IV and Bethesda V, this measurement was not useful in Bethesda I patients. In Bethesda III patients, patient-based decisions can be made according to their calcitonin measurement. https://www.bjbms.org/ojs/index.php/bjbms/article/view/5756Nodular thyroid diseasecalcitoninmedullary thyroid cancercytology |
| spellingShingle | Muhammed Erkam Sencar Sema Hepsen Murat Çalapkulu Hayri Bostan Davut Sakiz Ilknur Ozturk Unsal Hakan Duger Muhammed Kizilgul Bekir Ucan Tugba Taskin Turkmenoglu Mustafa Ozbek Erman Cakal The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytology Biomolecules & Biomedicine Nodular thyroid disease calcitonin medullary thyroid cancer cytology |
| title | The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytology |
| title_full | The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytology |
| title_fullStr | The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytology |
| title_full_unstemmed | The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytology |
| title_short | The value of routine measurement of serum calcitonin on insufficient, indeterminate, and suspicious thyroid nodule cytology |
| title_sort | value of routine measurement of serum calcitonin on insufficient indeterminate and suspicious thyroid nodule cytology |
| topic | Nodular thyroid disease calcitonin medullary thyroid cancer cytology |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/5756 |
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